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In graft\u2010versus\u2010host disease (GvHD) and transplant rejection, ECP is thought to induce immune tolerance by increasing regulatory CD4+ T\u2010cells, whereas in cutaneous T cell lymphoa it may enhance dendritic cell\u2013mediated antigen presentation and cytotoxic T cell activity. We investigated the role of CD8+ T cells in ECP using a murine model of multiple sclerosis (MS). ECP protected mice from disease, mitigated CNS pathology, and was dependent on CD8+ T cells. Translation to patients revealed increased numbers of suppressive CD8+ T\u2010cells. Functional assays identified enhanced suppressive capacity of CD8+ T\u2010cells in ECP patients and longitudinal studies found this occurred within 1\u2009month of starting ECP. Using both a murine model and clinical samples, our findings reveal a mechanistic role for suppressive CD8+ T\u2010cells in mediating the effects of ECP, potentially providing a unifying mechanism for ECP's apparently dichotomous effects.<\/jats:p>","DOI":"10.1002\/jca.70094","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T10:52:32Z","timestamp":1770461552000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Suppressive\n                    <scp>CD8<\/scp>\n                    + T\u2010Cells Are Key Cellular Mediators of Extracorporeal Photopheresis"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3331-5933","authenticated-orcid":false,"given":"Kai J.","family":"Rogers","sequence":"first","affiliation":[{"name":"Department of Pathology University of Iowa Health Care  Iowa City Iowa 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