{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:01:55Z","timestamp":1773032515032,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Lipoprotein apheresis (LA) is an established therapy for severe, drug\u2010refractory dyslipidemias. Nevertheless, clinicians often monitor hepatic and muscle enzymes during treatment because transient biochemical shifts can be misinterpreted as injury. In this study, we synthesize the evidence on how repeated apheresis sessions affect circulating enzymes. We systematically searched PubMed, Scopus and Web of Science from inception to August 2025 for observational human studies reporting pre\u2010 and post\u2010apheresis values (mean and SD) for aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma\u2010glutamyl transferase (GGT), lactate dehydrogenase (LDH), and creatine phosphokinase (CPK). Effects were expressed as weighted mean differences (WMD, IU\/L). Of 267 records screened, 9 articles (published 1998\u20132006) met eligibility for quantitative synthesis, yielding 9 ALT, 8 AST, 7 ALP, 6 GGT, 9 LDH and 6 CPK study estimates. Pooled analyses showed significant decreases in AST (WMD\u2009=\u2009\u22120.87; 95% CI: \u22121.51 to \u22120.23;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007), ALP (WMD\u2009=\u2009\u22126.28; CI: \u221211.75to \u22120.80;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02), LDH (WMD\u2009=\u2009\u221211.12; CI: \u221217.01 to \u22125.24;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001) and CPK (WMD\u2009=\u2009\u22126.91; CI: \u221213.06 to \u22120.75;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02). However, levels of ALT (WMD\u2009=\u2009\u22120.78; CI: \u22122.10 to 0.53;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.29) and GGT (WMD\u2009=\u2009\u22122.64; CI: \u22128.71 to 3.44;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.39) were unchanged. Across repeated\u2010session studies, LA does not elevate hepatic or muscle injury markers and is associated with modest reductions in AST, ALP, LDH, and CPK. These findings support the biochemical safety profile of apheresis and suggest that routine enzyme monitoring should be interpreted in context.\n                  <\/jats:p>","DOI":"10.1002\/jca.70100","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T04:25:42Z","timestamp":1771561542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Lipoprotein Apheresis on Changes in Biochemical Enzymes: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"41","author":[{"given":"Alireza","family":"Hatami","sequence":"first","affiliation":[{"name":"Department of Hematology and Blood Transfusion, Faculty of Medical Sciences Tarbiat Modares University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoud","family":"Eslami","sequence":"additional","affiliation":[{"name":"Department of Hematology and Blood Transfusion, Faculty of Medical Sciences Tarbiat Modares University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Aslani","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Clinical Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tannaz","family":"Jamialahmadi","sequence":"additional","affiliation":[{"name":"Pharmaceutical Research Center, Pharmaceutical Technology Institute Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahman","family":"Razi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Sciences and Hematology, School of Allied Medical Science North Khorasan University of Medical Sciences  Bojnurd Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8656-1444","authenticated-orcid":false,"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center, Pharmaceutical Technology Institute Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Centre for Research Impact &amp; Outcome, Chitkara College of Pharmacy Chitkara University  Rajpura Punjab India"},{"name":"Applied Biomedical Research Center, Basic Sciences Research Institute Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14796678.2024.2367860"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2014.07.002"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-013-6479-4"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2013.06.019"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2024.05.004"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2019.09.006"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-0968.2003.00051.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-0968.2003.00064.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.13548"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1594.1998.05080.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpc.2024.100649"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-021-00911-w"},{"issue":"5","key":"e_1_2_10_14_1","first-page":"413","article-title":"Lipoprotein 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