{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:01:51Z","timestamp":1773032511424,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Lipoprotein apheresis (LA) may influence hemostasis, but reported effects are inconsistent. We quantitatively assessed changes in fibrinogen, plasminogen, activated partial thromboplastin time (aPTT) and thrombin time (TT). Following PRISMA, PubMed, Scopus, and Web of Science were searched to August 2025 for observational human studies reporting pre\u2010\/post\u2010apheresis values. Weighted mean differences (WMD) with 95% confidence intervals (CIs) were pooled using random\u2010 or fixed\u2010effects models according to heterogeneity. Prespecified subgroups compared modality (DALI, HELP) and treatment duration (\u2264\u20091\u2009year, &gt;\u20091\u2009year). Meta\u2010regression, publication bias and leave\u2010one\u2010out sensitivity analyses were performed. From 678 records, 38 publications were eligible. LA reduced fibrinogen (60 studies;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091615; WMD\u2009=\u2009\u2212107.46\u2009mg\/dL, 95% CI: \u2212125.3 to \u221289.63;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and prolonged aPTT (14 studies;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009406; WMD\u2009=\u2009+47.9\u2009s, 95% CI: 34.29\u201361.51;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). No significant change was observed for plasminogen (5 studies;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009171; WMD\u2009=\u2009\u22121.89\u2009mg\/dL, 95% CI: \u22125.14 to 1.36;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.29) or TT (4 studies;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200954; WMD\u2009=\u2009+2.56\u2009s, 95% CI: \u22120.25 to 5.37;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.59). Fibrinogen fell with both modalities and durations, greater with HELP (\u2212139.13\u2009mg\/dL) than DALI (\u221258.9\u2009mg\/dL). aPTT increased with both, numerically larger with DALI (+90.21\u2009s) than with HELP (+26.95\u2009s). Repeated LA lowers fibrinogen and prolongs aPTT, with no clear pooled effect on plasminogen or TT. These findings support routine periprocedural coagulation monitoring and standardized reporting across modalities.\n                  <\/jats:p>","DOI":"10.1002\/jca.70103","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:11:32Z","timestamp":1773015092000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Lipoprotein Apheresis on Changes of Fibrinogen and\n                    <scp>aPTT<\/scp>\n                    : A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"41","author":[{"given":"Bahman","family":"Razi","sequence":"first","affiliation":[{"name":"Department of Laboratory Sciences and Hematology School of Allied Medical Science, North Khorasan University of Medical Sciences  Bojnurd Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoud","family":"Eslami","sequence":"additional","affiliation":[{"name":"Department of Hematology and Blood Transfusion Faculty of Medical Sciences, Tarbiat Modares University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Hatami","sequence":"additional","affiliation":[{"name":"Department of Hematology and Blood Transfusion Faculty of Medical Sciences, Tarbiat Modares University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Aslani","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Clinical Sciences, Monash University  Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tannaz","family":"Jamialahmadi","sequence":"additional","affiliation":[{"name":"Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"School of Pharmacy, Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8656-1444","authenticated-orcid":false,"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Applied Biomedical Research Center, Basic Sciences Research Institute, Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Centre for Research Impact &amp; Outcome, Chitkara College of Pharmacy, Chitkara University  Rajpura India"},{"name":"Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-019-0787-5"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2015.09.003"},{"issue":"11","key":"e_1_2_11_4_1","first-page":"444","article-title":"The Lipid\u2010and Lipoprotein\u2010[LDL\u2010Lp (a)] Apheresis Techniques. 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