{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T12:59:50Z","timestamp":1777294790940,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Guillain\u2010Barr\u00e9 syndrome (GBS) is a rare but severe neurological complication associated with COVID\u201019, often leading to significant morbidity. Plasma exchange (PE) is a cornerstone treatment for GBS, but its widespread use can be limited by hemodynamic instability and logistical challenges. Low\u2010volume plasma exchange (LVPE) has emerged as a safer alternative, providing comparable therapeutic benefits while minimizing procedural risks. This case report presents a patient with COVID\u201019\u2010associated GBS who underwent LVPE using a modified exchange protocol with a nanomembrane filtration system. This approach allowed for controlled plasma removal and minimized cardiovascular strain. Neurological rehabilitation was initiated simultaneously with LVPE, contributing to the patient's gradual recovery. Following the procedure and rehabilitation, the patient showed significant neurological improvement without notable adverse effects. These findings suggest that LVPE, in combination with rehabilitation, may be an effective therapeutic strategy, particularly in resource\u2010limited or high\u2010risk clinical settings. The results highlight the potential of LVPE as an adjunctive treatment for inflammatory neuropathies, especially in COVID\u201019\u2010related cases, and advocate for further investigation into its safety and efficacy.<\/jats:p>","DOI":"10.1002\/jca.70107","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:01:08Z","timestamp":1772989268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Safety and Efficacy of Low\u2010Volume Plasma Exchange in the Management of\n                    <scp>COVID\u201019\u2010<\/scp>\n                    Associated Guillain\u2010Barr\u00e9 Syndrome: A Case Report"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2014-3220","authenticated-orcid":false,"given":"Vjeroslava","family":"Slavic","sequence":"first","affiliation":[{"name":"Institute for Physical Medicine Rehabilitation and Rheumatology \u201cDr Simo Milosevic\u201d  Igalo Montenegro"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4184-8449","authenticated-orcid":false,"given":"Dragana","family":"Vucic","sequence":"additional","affiliation":[{"name":"Institute for Physical Medicine Rehabilitation and Rheumatology \u201cDr Simo Milosevic\u201d  Igalo Montenegro"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5566-5806","authenticated-orcid":false,"given":"Danijela","family":"Randjelovic","sequence":"additional","affiliation":[{"name":"Institute for Physical Medicine Rehabilitation and Rheumatology \u201cDr Simo Milosevic\u201d  Igalo Montenegro"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00522-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1570"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.594495"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202001-0179LE"},{"key":"e_1_2_9_6_1","article-title":"Neutrophil Extracellular Traps in COVID\u201019","volume":"5","author":"Zuo Y.","year":"2020","journal-title":"JCI Insight"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb8925"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.914411"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.608130"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2020-324837"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14860"},{"issue":"6","key":"e_1_2_9_12_1","first-page":"1","article-title":"Nanomembrane\u2010Based Apheresis: A Simple and Safe Procedure for Preventing Cardiovascular Complications in Metabolic Syndrome","volume":"6","author":"Slavic V.","year":"2024","journal-title":"Journal of Physical Medicine and Rehabilitation Studies and Reports"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27159"},{"key":"e_1_2_9_14_1","article-title":"Guillain\u2010Barr\u00e9 Syndrome and Link With COVID\u201019 Infection and Vaccination: A Review of Literature","volume":"13","author":"Valaparla V. K.","year":"2024","journal-title":"Frontiers in Neurology"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.102875"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21705"},{"issue":"4","key":"e_1_2_9_17_1","first-page":"507","article-title":"Plasma Exchange and Apheresis in Guillain\u2010Barr\u00e9 Syndrome: A Review of Clinical Indications and Outcomes","volume":"25","author":"Dhakal B. P.","year":"2021","journal-title":"Therapeutic Apheresis and Dialysis"},{"issue":"9","key":"e_1_2_9_18_1","first-page":"3741","article-title":"SARS\u2010CoV\u20102\u2010Related Guillain\u2010Barr\u00e9 Syndrome: The Role of Therapeutic Plasma Exchange","volume":"42","author":"Lu L.","year":"2021","journal-title":"Neurological Sciences"},{"issue":"6","key":"e_1_2_9_19_1","first-page":"479","article-title":"Use of Plasmapheresis in Guillain\u2010Barr\u00e9 Syndrome","volume":"40","author":"Al\u2010Jehani H.","year":"2020","journal-title":"Annals of Saudi Medicine"},{"key":"e_1_2_9_20_1","first-page":"53","article-title":"Immunomodulatory Therapies in Guillain\u2010Barr\u00e9 Syndrome and COVID\u201019","volume":"94","author":"Khuu W.","year":"2022","journal-title":"Journal of Clinical Neuroscience"},{"issue":"9","key":"e_1_2_9_21_1","first-page":"e811","article-title":"Mechanisms and Clinical Indications of Nanomembrane\u2010Based Therapeutic Apheresis in Critical Illness","volume":"50","author":"Donadello K.","year":"2022","journal-title":"Critical Care Medicine"}],"container-title":["Journal of Clinical Apheresis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.70107","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jca.70107","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.70107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T12:00:19Z","timestamp":1777291219000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jca.70107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,4]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/jca.70107"],"URL":"https:\/\/doi.org\/10.1002\/jca.70107","archive":["Portico"],"relation":{},"ISSN":["0733-2459","1098-1101"],"issn-type":[{"value":"0733-2459","type":"print"},{"value":"1098-1101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,4]]},"assertion":[{"value":"2025-07-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70107"}}