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HL, most often defined as WBC\u2009&gt;\u2009100\u2009000\/\u03bcL, is a hematologic emergency associated with severe complications, early mortality, and poor prognosis, requiring immediate intervention. From November 2005 to September 2025, 65 newly diagnosed AML patients with HL underwent leukocytapheresis (LCP) at University Hospital Olomouc. Clinical data were retrospectively collected from medical records. The primary objective was to evaluate the procedural efficacy and safety. Clinical and laboratory data were analyzed. Survival outcomes were assessed by Kaplan\u2013Meier analysis and compared using the log\u2010rank test. Median age at diagnosis was 57\u2009years. Dyspnea (60.0%), neuropsychiatric symptoms (31.7%), and visual impairment (6.2%) were the most common leukostasis manifestations. LCP effectively reduced WBC counts without significant adverse events, median of 2.2 TBV was treated, and 52.3% of the patients requiring more than one session.\n                    <jats:italic>FLT3<\/jats:italic>\n                    \u2010ITD and\n                    <jats:italic>NPM1<\/jats:italic>\n                    mutations were detected in 26\/46 (56.5%) and 17\/43 (39.5%), respectively,\n                    <jats:italic>KMT2A<\/jats:italic>\n                    rearrangements were present in 5\/57 (8.8%). Intensive chemotherapy was feasible in 56.9% of patients, with 26.2% undergoing allo\u2010HSCT. Median OS was 5.9\u2009months (95% CI: 1.3\u20138.4), significantly longer in therapy\u2010eligible patients, but outcomes remained poor, highlighting HL as an unmet clinical need. LCP remains a valuable therapeutic option for patients with HL in newly diagnosed AML. Our long\u2010term experience supports its safety and efficacy, particularly in symptomatic patients, as a bridge to definitive therapy regardless of treatment intensity eligibility.\n                  <\/jats:p>","DOI":"10.1002\/jca.70111","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T05:59:26Z","timestamp":1773727166000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Twenty Years of Therapeutic Leukocytapheresis in Newly Diagnosed Acute Myeloid Leukemia: Insights From A Single Center"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0775-4898","authenticated-orcid":false,"given":"Vojtech","family":"Latal","sequence":"first","affiliation":[{"name":"Department of Hemato\u2010Oncology, Faculty of Medicine and Dentistry Palacky University Olomouc and University Hospital Olomouc  Olomouc 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University Olomouc and University Hospital Olomouc  Olomouc Czech\u00a0Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Cernan","sequence":"additional","affiliation":[{"name":"Department of Hemato\u2010Oncology, Faculty of Medicine and Dentistry Palacky University Olomouc and University Hospital Olomouc  Olomouc Czech\u00a0Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5329-8002","authenticated-orcid":false,"given":"Jana","family":"Navratilova","sequence":"additional","affiliation":[{"name":"Department of Hemato\u2010Oncology, Faculty of Medicine and Dentistry Palacky University Olomouc and University Hospital Olomouc  Olomouc Czech\u00a0Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8499-2961","authenticated-orcid":false,"given":"Helena","family":"Urbankova","sequence":"additional","affiliation":[{"name":"Department of Hemato\u2010Oncology, Faculty of Medicine and Dentistry Palacky University Olomouc and University Hospital Olomouc  Olomouc Czech\u00a0Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuzana","family":"Pikalova","sequence":"additional","affiliation":[{"name":"Department of Hemato\u2010Oncology, Faculty of Medicine and Dentistry Palacky University Olomouc and University Hospital Olomouc  Olomouc Czech\u00a0Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludek","family":"Raida","sequence":"additional","affiliation":[{"name":"Department of Hemato\u2010Oncology, Faculty of Medicine and Dentistry Palacky University Olomouc and University Hospital Olomouc  Olomouc Czech\u00a0Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3259-7791","authenticated-orcid":false,"given":"Edgar","family":"Faber","sequence":"additional","affiliation":[{"name":"Department of Hemato\u2010Oncology, Faculty of 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