{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T12:59:32Z","timestamp":1777294772599,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:00:00Z","timestamp":1774137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:00:00Z","timestamp":1774137600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Donor specific human leukocyte antigen antibodies are associated with increased risk of rejection, worse post\u2010transplant outcomes, and longer waitlist times due to the immunological risks. Intraoperative therapeutic plasma exchange (iTPE) represents a potential strategy to mitigate the immunological risk. This study aims to evaluate the clinical outcomes associated with the use of iTPE in sensitized heart transplant recipients. This retrospective, single\u2010center cohort study included 59 adult heart transplant recipients. Patients were categorized into three groups: those receiving iTPE (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200920), sensitized patients without iTPE (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200919), and unsensitized patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200920). We assessed recipient survival, antibody\u2010mediated rejection (AMR) and infection free survival, waitlist time, and length of intensive care unit (ICU) and hospital stay. The overall cohort had a median age of 58\u2009years with predominantly female patients (61%). The iTPE group exhibited a higher percentage of donor specific antibody positive and positive flow cytometry crossmatch results. Unsensitized patients had shorter wait times, but there was no difference between the iTPE and sensitized groups. There was no statistically significant difference in ICU and hospital stay, one\u2010year and three\u2010year survival, and AMR\u2010free survival among the groups. The iTPE group had the lowest infection\u2010free survival at 1\u2009year. In conclusion, we report that iTPE may serve as an effective adjunct to immunosuppressive therapy for higher immunological risk heart transplant recipients with comparable AMR\u2010free survival, 1\u2010 and 3\u2010year survival. However, increased susceptibility to infections with iTPE underscores the infection management strategies post\u2010transplant. Larger, multi\u2010center cohort studies are necessary.\n                  <\/jats:p>","DOI":"10.1002\/jca.70115","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T04:26:58Z","timestamp":1774240018000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intraoperative Therapeutic Plasma Exchange for Sensitized Heart Transplant Candidates"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1736-994X","authenticated-orcid":false,"given":"Furkan","family":"Yigitbilek","sequence":"first","affiliation":[{"name":"Department of Pathology Stanford University School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juka S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiology Stanford University School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik J.","family":"Henricksen","sequence":"additional","affiliation":[{"name":"Department of Transplant Stanford University School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8342-3222","authenticated-orcid":false,"given":"Jeffrey J.","family":"Teuteberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology Stanford University School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9697-5926","authenticated-orcid":false,"given":"Kiran K.","family":"Khush","sequence":"additional","affiliation":[{"name":"Department of Cardiology Stanford University School of Medicine  Stanford California 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