{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:48:42Z","timestamp":1782460122605,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The objective of this in\u00a0vitro experimental was to determine the utility of hemoadsorption (HA) using the CytoSorb adsorber to remove meloxicam and diclofenac from porcine plasma. For this purpose 12 1\u2010L aliquots of porcine plasma, 6\u2009units were spiked with 293\u2009\u03bcg\/mL (262\u2013320\u2009\u03bcg\/mL) diclofenac and 6 with 42.8\u2009\u03bcg\/mL (41.4\u201344.7\u2009\u03bcg\/mL) meloxicam, respectively. Each unit was processed in a circular setup with the CytoSorb adsorber using the PuriFi HA platform until a recirculated volume of 20\u2009L was reached. Pre\u2010 and post\u2010adsorber samples were obtained at seven time points. Percentage reduction, clearance, and change from baseline were calculated. Drug concentrations were compared using Friedmann test with post hoc Dunn's multiple comparison test and Wilcoxon matched pairs rank sum test.\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05 were considered significant. Diclofenac was reduced by a median of 242\u2009mg (204\u2013262\u2009mg; 82.1%; 77.0%\u201383.6%). Total clearance was 40.5\u2009mL\/min (33.2\u201346.2\u2009mL\/min). Clearance at a plasma flow of 100\u2009mL\/min decreased from 39.9\u2009mL\/min (25.3\u201346.6\u2009mL\/min) at 0.2\u2009L to 6.4\u2009mL\/min (\u22123.8 to 14.8\u2009mL\/min) at 20\u2009L. Median reduction of meloxicam was 40.4\u2009mg (38.6\u201342.2\u2009mg; 94.4%; 93.2%\u201394.6%); total clearance was 94.38\u2009mL\/min (93.2\u201394.6\u2009mL\/min). Clearance at a plasma flow of 100\u2009mL\/min decreased from 65.3\u2009mL\/min (56.7\u201371.7\u2009mL\/min) at 0.2\u2009L to 3.6\u2009mL\/min (\u221213.0 to 4.2\u2009mL\/min) at 20\u2009L. HA using the CytoSorb adsorber successfully removed meloxicam and diclofenac from porcine plasma.\n                  <\/jats:p>","DOI":"10.1002\/jca.70130","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:00:41Z","timestamp":1777644041000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Hemoadsorption Capacity of the\n                    <scp>CytoSorb<\/scp>\n                    Adsorber for Toxic Doses of Diclofenac and Meloxicam in Porcine Plasma"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9052-1462","authenticated-orcid":false,"given":"Bettina","family":"Giani","sequence":"first","affiliation":[{"name":"LMU Small Animal Clinic, Center for Clinical Veterinary Medicine, Faculty of Veterinary Medicine Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1831-377X","authenticated-orcid":false,"given":"Ren\u00e9","family":"D\u00f6rfelt","sequence":"additional","affiliation":[{"name":"LMU Small Animal Clinic, Center for Clinical Veterinary Medicine, Faculty of Veterinary Medicine Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Hartmann","sequence":"additional","affiliation":[{"name":"LMU Small Animal Clinic, Center for Clinical Veterinary Medicine, Faculty of Veterinary Medicine Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"S\u00e4nger","sequence":"additional","affiliation":[{"name":"LMU Small Animal Clinic, Center for Clinical Veterinary Medicine, Faculty of Veterinary Medicine Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2024.2412423"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041\u2010008X(03)00368\u20105"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/OAEM.S22795"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfs310"},{"key":"e_1_2_9_6_1","unstructured":"National Center for Biotechnology Information \u201cPubChem Compound Summary for CID 3033 \u201dDiclofenac C14H11Cl2NO2 CID 3033 PubChem 2025 https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Diclofenac."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511722172.011"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088\u2010199733030\u201000003"},{"key":"e_1_2_9_9_1","volume-title":"Katzung's Basic & Clinical Pharmacology: A Lange Medical Book","author":"Furst D. 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