{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:48:42Z","timestamp":1782460122609,"version":"3.54.5"},"reference-count":5,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Therapeutic plasma exchange (TPE) is an established treatment modality in the management of acute liver failure, with evidence from multicenter randomized controlled trials demonstrating improved overall survival in affected patients. In this setting, massive hepatic necrosis, release of pro\u2010inflammatory cytokines, and the onset of multi\u2010organ failure driven by a systemic inflammatory response all contribute significantly to mortality. TPE offers potential benefits through the removal of circulating cytokines and toxins, alongside the replacement of critical plasma proteins, including coagulation factors. However, its application in pediatric populations presents unique challenges, particularly in infants with very low body weight. Here, we describe the case of a 6\u2010month\u2010old infant with end\u2010stage liver disease secondary to biliary atresia, in whom TPE was successfully implemented as a bridging strategy to urgent liver transplantation despite profound hepatic dysfunction and a body weight of just 4.9\u2009kg. This case highlights the need for individualized protocol adaptation and careful physiological monitoring to ensure safe and effective apheresis in this patient population.<\/jats:p>","DOI":"10.1002\/jca.70134","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T04:50:23Z","timestamp":1779166223000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plasmapheresis in Low Body Weight Infant With Acute Liver Failure"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4117-4889","authenticated-orcid":false,"given":"Katja","family":"Kimberger","sequence":"first","affiliation":[{"name":"NHS Blood and Transplant, Therapeutic Apheresis Service  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Blacklock\u2010Lumb","sequence":"additional","affiliation":[{"name":"NHS Blood and Transplant, Therapeutic Apheresis Service  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Armitage","sequence":"additional","affiliation":[{"name":"NHS Blood and Transplant, Therapeutic Apheresis Service  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.08.018"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.01.036"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.22043"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21301"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537\u20102995.2007.01405.x"}],"container-title":["Journal of Clinical Apheresis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.70134","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jca.70134","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.70134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:16:28Z","timestamp":1782458188000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jca.70134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,18]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/jca.70134"],"URL":"https:\/\/doi.org\/10.1002\/jca.70134","archive":["Portico"],"relation":{},"ISSN":["0733-2459","1098-1101"],"issn-type":[{"value":"0733-2459","type":"print"},{"value":"1098-1101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,18]]},"assertion":[{"value":"2026-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70134"}}