{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:41:07Z","timestamp":1792622467909,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Microplastic particles (MP) from industrial products and degradation of plastic waste are ubiquitous in our environment and convey serious potential risks to human health. There is currently no established method for removing MP from the human body. MP circulate in the blood and have been found in the eluate plasma from double filtration plasmapheresis procedures, suggesting that plasmapheresis could be used to remove MP from the body. We have measured circulating MP in the blood of 114 patients before and after 174 1\u2010plasma\u2010volume therapeutic plasma exchange (TPE) procedures using the Spectra Optia Apheresis System and have shown that circulating MP are reduced by TPE. The reduction is obscured at low starting levels of MP because of leaching of MP back into the circulation from the plastic apheresis tubing set. Nonetheless, this is the first demonstration that it is possible to reduce circulating MP in human patients.<\/jats:p>","DOI":"10.1002\/jca.70135","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T06:17:37Z","timestamp":1779430657000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Can Plasma Exchange Be Used to Lower the Circulating Burden of Microplastics in Human Patients?"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3895-8401","authenticated-orcid":false,"given":"Robert","family":"Weinstein","sequence":"first","affiliation":[{"name":"Department of Medicine University of Massachusetts Chan Medical School  Worcester Massachusetts USA"},{"name":"Circulate Health  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehra Stara","family":"Yuksel","sequence":"additional","affiliation":[{"name":"Circulate Health  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Anderson","sequence":"additional","affiliation":[{"name":"Circulate Health  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Grant","sequence":"additional","affiliation":[{"name":"Circulate Health  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Milius","sequence":"additional","affiliation":[{"name":"Circulate Health  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Waldron","sequence":"additional","affiliation":[{"name":"Circulate Health  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lou Ann","family":"David","sequence":"additional","affiliation":[{"name":"Circulate Health  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charesse","family":"Molina","sequence":"additional","affiliation":[{"name":"Circulate Health  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilene S.","family":"Ruhoy","sequence":"additional","affiliation":[{"name":"Atria Health Institute  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Center for Complex Diseases  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Renna","sequence":"additional","affiliation":[{"name":"Lifespan Health  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Comite","sequence":"additional","affiliation":[{"name":"Center for Precision Medicine &amp; Healthy Longevity  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad","family":"Younggren","sequence":"additional","affiliation":[{"name":"Circulate Health  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.118190"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1029\/2018JC014719"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2309822"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.134455"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.136193"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2024.118535"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101581"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.3c09524"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/envhealth.3c00052"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.14.04179"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.168946"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.61373\/bm025l.0056"},{"key":"e_1_2_11_14_1","article-title":"Dried Blood Spots \u2010 Preparing and Processing for Use in Immunoassays and in Molecular Techniques","volume":"97","author":"Gr\u00fcner N.","year":"2015","journal-title":"Journal of Visualized Experiments"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.marpolbul.2016.10.049"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2022.107199"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep44501"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.4300\/JGME-D-12-00156.1"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41370-023-00634-x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1182-2016"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/envhealth.4c00210"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep46687"}],"container-title":["Journal of Clinical Apheresis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.70135","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jca.70135","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.70135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:15:16Z","timestamp":1792620916000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jca.70135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/jca.70135"],"URL":"https:\/\/doi.org\/10.1002\/jca.70135","archive":["Portico"],"relation":{},"ISSN":["0733-2459","1098-1101"],"issn-type":[{"value":"0733-2459","type":"print"},{"value":"1098-1101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,21]]},"assertion":[{"value":"2026-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70135"}}