{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:48:39Z","timestamp":1782460119968,"version":"3.54.5"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Erosive Lichen Planus (ELP) is a debilitating T\u2010cell mediated dermatosis often refractory to conventional therapies. While Extracorporeal Photopheresis (ECP) is established for other T\u2010cell diseases, long\u2010term data on its efficacy across the lichenoid spectrum, including non\u2010erosive forms, remain limited. We conducted a retrospective study at Amiens\u2010Picardie University Hospital including five adult patients with refractory lichen (erosive or non\u2010erosive) treated with ECP after January 2021. Clinical response was assessed every 3\u2009months, and progression\u2010free survival (PFS) was analyzed. Five female patients were included: 3 with ELP and 2 with lichen sclerosus (LS) variants. All patients achieved an initial clinical response (1 complete, 4 partial). The median time to best response was 7.5\u2009months (95% CI: 0.8\u201313). At 3\u2009months, 40% were on ECP monotherapy. Over a median follow\u2010up of 47\u2009months, only one patient progressed. At the last follow\u2010up, two patients remained on ECP with sustained clinical benefit. Our results confirm the excellent long\u2010term efficacy and safety of ECP in refractory ELP. While significant initial benefits were observed in non\u2010erosive scleroatrophic lichen, the durability of response warrants further investigation. ECP is an effective, well\u2010tolerated, and sustained therapeutic option for refractory ELP and holds promise for non\u2010erosive lichenoid pathologies. Larger prospective studies are needed to clarify its role as monotherapy versus combination therapy.<\/jats:p>","DOI":"10.1002\/jca.70136","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T04:20:49Z","timestamp":1781670049000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extracorporeal Photopheresis (\n                    <scp>ECP<\/scp>\n                    ) for Refractory Lichenoid Disorders: A Retrospective Analysis of Efficacy and Long\u2010Term Outcomes"],"prefix":"10.1002","volume":"41","author":[{"given":"Etienne","family":"Paubelle","sequence":"first","affiliation":[{"name":"Cell Therapy Laboratory Amiens University Hospital  Amiens France"},{"name":"Apheresis Unit Amiens University Hospital  Amiens France"},{"name":"HEMATIM\u2014Haematopoiesis and Immunology (UR UPJV 4666)  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavinia","family":"Merlusca","sequence":"additional","affiliation":[{"name":"Apheresis Unit Amiens University Hospital  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Petit","sequence":"additional","affiliation":[{"name":"Apheresis Unit Amiens University Hospital  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Theophile","sequence":"additional","affiliation":[{"name":"Apheresis Unit Amiens University Hospital  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein","family":"Ghamlouch","sequence":"additional","affiliation":[{"name":"Cell Therapy Laboratory Amiens University Hospital  Amiens France"},{"name":"HEMATIM\u2014Haematopoiesis and Immunology (UR UPJV 4666)  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel","family":"Ossart","sequence":"additional","affiliation":[{"name":"Cell Therapy Laboratory Amiens University Hospital  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solenn","family":"Bacquet","sequence":"additional","affiliation":[{"name":"Cell Therapy Laboratory Amiens University Hospital  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Pierre","family":"Marolleau","sequence":"additional","affiliation":[{"name":"Cell Therapy Laboratory Amiens University Hospital  Amiens France"},{"name":"Apheresis Unit Amiens University Hospital  Amiens France"},{"name":"HEMATIM\u2014Haematopoiesis and Immunology (UR UPJV 4666)  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Philippe","family":"Arnault","sequence":"additional","affiliation":[{"name":"Dermatology Department Amiens University Hospital  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.2013.10"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20164046"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1106318"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2024.103990"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-024-02360-w"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-0502(03)00103-4"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14070692"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1992.tb00974.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2012.02814.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07647.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2019.02.011"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00349"}],"container-title":["Journal 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