{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:20:19Z","timestamp":1787905219264,"version":"build-2784847793"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Collection of hematopoietic progenitor cells and mononuclear cells by leukocytapheresis is a critical step of procuring cellular starting materials for future therapeutic use. Leukocytapheresis requires use of anticoagulant to prevent blood clotting in the extracorporeal circuit during collection. A commonly used anticoagulant is Acid Citrate Dextrose Solution A (ACD\u2010A). ACD\u2010A primarily prevents blood clotting by reversibly chelating free ionized calcium, which is essential for the clotting cascade. Electrolytes frequently affected by ACD\u2010A include calcium, magnesium, potassium, phosphate, and bicarbonate. Risks for development of electrolyte derangements include procedure\u2010related parameters as well as patient comorbidities. Symptoms range from mild paresthesias to life\u2010threatening cardiac arrhythmias. Recognition of related signs and symptoms is important for prompt intervention with procedure modification and electrolyte replacement to optimize patient safety. This paper will provide an enhanced understanding of the underlying pathophysiology and assist in timely identification and management of electrolyte abnormalities associated with cellular therapy collections.<\/jats:p>","DOI":"10.1002\/jca.70151","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:07:17Z","timestamp":1783080437000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Calcium and Other Electrolyte Management in Patients Undergoing Leukocytapheresis Collections: Review and Recommendations From the American Society for Apheresis Clinical Applications Committee"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8406-1386","authenticated-orcid":false,"given":"Lance A.","family":"Williams","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1734-1521","authenticated-orcid":false,"given":"Elizabeth A.","family":"Godbey","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0373-9930","authenticated-orcid":false,"given":"Reuben P.","family":"Jacob","sequence":"additional","affiliation":[{"name":"Aflac Cancer and Blood Disorders Center, Department of Pediatrics Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Department of Pathology and Laboratory Medicine Children's Healthcare of Atlanta  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5287-6472","authenticated-orcid":false,"given":"Amber P.","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine University of California San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Bailey","sequence":"additional","affiliation":[{"name":"Department of Blood and Marrow Transplant and Cellular Immunotherapy Moffitt Cancer Center  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Revia","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Colorado, Anschutz School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9881-703X","authenticated-orcid":false,"given":"Suzanne","family":"Thibodeaux","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology WashU Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9945-4381","authenticated-orcid":false,"given":"Hien D.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Blood and Marrow Transplant and Cellular Immunotherapy Moffitt Cancer Center  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7192-5057","authenticated-orcid":false,"given":"Kyle","family":"Annen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology WashU Medicine  St. Louis Missouri USA"},{"name":"Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21222"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1101(2000)15:4<230::AID-JCA3>3.0.CO;2-B"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.07400715"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.2478\/jtim-2018-0026"},{"key":"e_1_2_17_6_1","first-page":"59","volume-title":"Apheresis: Principles and Practice. 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