{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:21:53Z","timestamp":1787905313474,"version":"build-2784847793"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Acquired von Willebrand disease (AvWD) in myeloproliferative neoplasms with extreme thrombocytosis causes paradoxical bleeding due to the mechanism of adsorption and ADAMTS13\u2010mediated proteolysis of high\u2010molecular\u2010weight von Willebrand factor (vWF) multimers. When first\u2010line cytoreductive therapy fails due to intolerance or nonadherence, rapid alternatives are limited. We describe a 74\u2010year\u2010old woman with JAK2V617F\u2010mutated myeloproliferative neoplasm and hydroxyurea intolerance who presented with active mucosal bleeding and a platelet count of 952\u2009000\/\u03bcL. vWF antigen (vWF:Ag) was 0.37\u2009IU\/mL (reference range: 0.50\u20132.00\u2009IU\/mL), and vWF Ristocetin Cofactor activity (vWF:RCo) was 0.21\u2009IU\/mL (activity\/antigen ratio 0.57; reference range 0.7\u20131.3), consistent with AvWD. A single thrombocytapheresis session on the Fresenius COM.TEC platform reduced the platelet count to 277\u2009000\/\u03bcL, with prompt cessation of bleeding. Repeat testing at 24\u2009h showed improvement in vWF:RCo to 0.48\u2009IU\/mL (ratio 0.68), which likely reflects restoration of functional high\u2010molecular\u2010weight multimers. In this single case, thrombocytapheresis provided rapid and effective platelet reduction for AvWD secondary to myeloproliferative neoplasms when pharmacological cytoreduction is inadequate.<\/jats:p>","DOI":"10.1002\/jca.70152","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T05:27:21Z","timestamp":1782710841000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thrombocytapheresis as a Bridge Intervention in\n                    <scp>JAK2<\/scp>\n                    \u2010Mutant Myeloproliferative Neoplasm Complicated by Acquired von Willebrand Disease: A Case Report"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8664-8483","authenticated-orcid":false,"given":"Abbas Ghazi","family":"Naqvi","sequence":"first","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion Armed Forces Medical College  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8979-975X","authenticated-orcid":false,"given":"Akshaya","family":"Tomar","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion Armed Forces Medical College  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0998-9893","authenticated-orcid":false,"given":"Neerja","family":"Kushwaha","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion Armed Forces Medical College  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8155-0559","authenticated-orcid":false,"given":"Anis","family":"Maaheraa L.","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion Armed Forces Medical College  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMA.2024.25349"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010020\u20100945\u20103"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12071746"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.255117"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2023.102284"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.5124\/JKMA.2023.66.4.253"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16682"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/JCA.21683"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102010\u201011\u2010297580"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.15386\/mpr\u20101954"}],"container-title":["Journal of Clinical Apheresis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.70152","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jca.70152","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.70152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:00:56Z","timestamp":1787904056000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jca.70152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,28]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/jca.70152"],"URL":"https:\/\/doi.org\/10.1002\/jca.70152","archive":["Portico"],"relation":{},"ISSN":["0733-2459","1098-1101"],"issn-type":[{"value":"0733-2459","type":"print"},{"value":"1098-1101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,28]]},"assertion":[{"value":"2026-04-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70152"}}