{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:21:53Z","timestamp":1787905313402,"version":"build-2784847793"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Lipoprotein apheresis (LA) is used for severe dyslipidemia but can remove non\u2010lipid plasma constituents. In this systematic review and meta\u2010analysis, we synthesized evidence on LA\u2010associated changes in albumin, total protein (TP), and \u03b12\u2010macroglobulin (\u03b12M). PubMed, Scopus, and Web of Science were searched from inception to August 2025 for human observational studies reporting pre\u2010\/post\u2010apheresis values for albumin, TP, or \u03b12M. Pooled effects were summarized as weighted mean differences (WMD) with 95% CIs. Prespecified subgroup analyses included apheresis duration (\u2265\u20091\u2009year vs. &lt;\u20091\u2009year), disease background, and apheresis method. Twenty\u2010eight publications met eligibility (albumin: 22 publications\/39 studies;\n                    <jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>\n                    : 21 publications\/34 studies;\n                    <jats:styled-content style=\"fixed-case\">\u03b12M<\/jats:styled-content>\n                    : 6 publications\/7 studies).\n                    <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\n                    was associated with lower post\u2010procedure levels of albumin (\n                    <jats:styled-content style=\"fixed-case\">WMD<\/jats:styled-content>\n                    \u2009=\u2009\u22123.80\u2009g\/L; 95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    : \u22124.61 to \u22122.99;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001),\n                    <jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>\n                    (\n                    <jats:styled-content style=\"fixed-case\">WMD<\/jats:styled-content>\n                    \u2009=\u2009\u22128.73\u2009g\/L; 95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    : \u221211.06 to \u22126.41;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and\n                    <jats:styled-content style=\"fixed-case\">\u03b12M<\/jats:styled-content>\n                    (\n                    <jats:styled-content style=\"fixed-case\">WMD<\/jats:styled-content>\n                    \u2009=\u2009\u221265.79\u2009mg\/\n                    <jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content>\n                    ; 95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    : \u221288.98 to \u221242.60;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Reductions were observed across durations (&lt;\u20091\u2009year and \u2265\u20091\u2009year), disease groups, and apheresis methods, with larger albumin decreases in\n                    <jats:styled-content style=\"fixed-case\">DALI<\/jats:styled-content>\n                    \u2010based protocols and smaller in other methods. Between\u2010study heterogeneity was high but diminished in several subgroups; meta\u2010regression suggested background disease as a potential contributor. Across observational studies,\n                    <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\n                    reduced albumin,\n                    <jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>\n                    , and\n                    <jats:styled-content style=\"fixed-case\">\u03b12M<\/jats:styled-content>\n                    immediately post\u2010procedure. Magnitudes vary by method, clinical context, and treatment duration. These findings support routine monitoring of protein profiles during maintenance\n                    <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/jca.70160","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T01:33:22Z","timestamp":1785288802000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Lipoprotein apheresis on Plasma Protein Levels: A Meta\u2010Analysis"],"prefix":"10.1002","volume":"41","author":[{"given":"Saeed","family":"Aslani","sequence":"first","affiliation":[{"name":"Department of Surgery School of Clinical Sciences, Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Eslami","sequence":"additional","affiliation":[{"name":"Department of Hematology and Blood Transfusion Faculty of Medical Sciences, Tarbiat Modares University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Hatami","sequence":"additional","affiliation":[{"name":"Department of Hematology and Blood Transfusion Faculty of Medical Sciences, Tarbiat Modares University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahab","family":"Alizadeh","sequence":"additional","affiliation":[{"name":"Clinical Research Development Center, Baharloo Hospital Tehran University of Medical Sciences (TUMS)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahman","family":"Razi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Sciences and Hematology Faculty of Allied Medical Sciences, North Khorasan University of Medical Sciences  Bojnurd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0312-9910","authenticated-orcid":false,"given":"Wael","family":"Almahmeed","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Cleveland Clinic Abu Dhabi  Abu Dhabi UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tannaz","family":"Jamialahmadi","sequence":"additional","affiliation":[{"name":"Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8656-1444","authenticated-orcid":false,"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Centre for Research Impact &amp; 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