{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:54:39Z","timestamp":1791906879716,"version":"4.3.4"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Acute kidney failure from light chain cast nephropathy is a serious complication of multiple myeloma. Plasma exchange (PLEX) has been used to remove circulating free light chains (FLCs), but its benefit in the modern treatment era remains uncertain. We performed a retrospective multicenter cohort study using the TriNetX Research Network to identify newly diagnosed multiple myeloma cases presenting between 2014 and 2024 with acute kidney failure and FLC levels\u2009&gt;\u20091500\u2009mg\/L. Patients were classified by receipt of PLEX within 7\u2009days. Propensity score matching incorporated demographics, comorbidities, laboratory values, and initial myeloma\u2010directed therapies. The primary outcome was dialysis dependence at 90\u2009days. Secondary outcomes included dialysis dependence at 180\u2009days, mortality, renal recovery (creatinine\u2009&lt;\u20092.0\u2009mg\/dL), ICU admission within 7\u2009days, and dialysis\u2010free survival. Among 5454 eligible patients, 251 (4.6%) received PLEX. After matching, 248 patients were included in each group. PLEX was not associated with reduced dialysis dependence at 90 (16.1% vs. 18.1%; OR 0.87, 95% CI 0.54\u20131.39) or 180\u2009days (18.5% vs. 20.2%; OR 0.90, 95% CI 0.58\u20131.41). Mortality, ICU admission, and dialysis\u2010free survival were also similar. PLEX was not associated with improved dialysis independence or survival, supporting rapid initiation of effective anti\u2010myeloma therapy.<\/jats:p>","DOI":"10.1002\/jca.70167","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T03:40:19Z","timestamp":1785987619000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Plasma Exchange in Myeloma\u2010Associated Acute Kidney Injury: A Multicenter Propensity\u2010Matched Cohort Study"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9905-7139","authenticated-orcid":false,"given":"Joseph","family":"O'Brien","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Denver Health Medical Center  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica S.","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Medicine Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niraj B.","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5424-5519","authenticated-orcid":false,"given":"Robert W.","family":"Maitta","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division of Transfusion Medicine University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology\/Oncology University Hospitals Cleveland Medical Center  Cleveland Ohio 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