{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:03:45Z","timestamp":1789452225719,"version":"build-2803163510"},"reference-count":7,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2026,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Therapeutic plasma exchange is a second\u2010line therapy for severe hyperthyroidism when anti\u2010thyroid drugs (ATD) are contraindicated or ineffective. We report five patients (three males, two females, age range: 30\u201370\u2009years old): ATD\u2010induced agranulocytosis (\n n<\/jats:italic>\n \u2009=\u20092); ATD\u2010induced cholestatic hepatitis (\n n<\/jats:italic>\n \u2009=\u20091); refractory hyperthyroidism with large goiter (\n n<\/jats:italic>\n \u2009=\u20091); thyroid storm during pregnancy (\n n<\/jats:italic>\n \u2009=\u20091). A total of six TPE sessions were performed (five with fresh frozen plasma, one with 5% albumin). Among sessions with quantifiable baseline fT4, levels decreased by a mean of 39.0% per session; two sessions had baseline fT4 above the assay's upper limit of quantification, precluding exact calculation, though both showed reductions of at least 50%. Four patients underwent successful thyroidectomy; one continued medical management. No intraoperative thyroid storms occurred. TPE could be an effective bridging strategy for patients with severe hyperthyroidism and ATD intolerance.\n <\/jats:p>","DOI":"10.1002\/jca.70171","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T04:07:01Z","timestamp":1786939621000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic Plasma Exchange for Complicated Hyperthyroidism: A Case Series"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4898-0987","authenticated-orcid":false,"given":"Hen Huu","family":"Phan","sequence":"first","affiliation":[{"name":"Department of Endocrinology Cho Ray Hospital Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1001-413X","authenticated-orcid":false,"given":"Thien Quoc","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Cho Ray Hospital Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9997-6390","authenticated-orcid":false,"given":"Minh Duc","family":"Do","sequence":"additional","affiliation":[{"name":"Center for Molecular Biomedicine University of Medicine and Pharmacy Ho Chi Minh Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ16-0336"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.19052"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2011.01003.x"},{"issue":"2","key":"e_1_2_8_5_1","first-page":"77","article-title":"Guidelines on the Use of Therapeutic Apheresis: 9th Special Issue","volume":"38","author":"Connelly\u2010Smith L.","year":"2023","journal-title":"Journal of Clinical Apheresis"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10047-024-01476-6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcemcr\/luaf240"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1530\/EDM-24-0150"}],"updated-by":[{"DOI":"10.1002\/jca.70180","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000}}],"container-title":["Journal of Clinical Apheresis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.70171","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jca.70171","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.70171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:00:44Z","timestamp":1787904044000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jca.70171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/jca.70171"],"URL":"https:\/\/doi.org\/10.1002\/jca.70171","archive":["Portico"],"relation":{},"ISSN":["0733-2459","1098-1101"],"issn-type":[{"value":"0733-2459","type":"print"},{"value":"1098-1101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70171"}}