{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:55:39Z","timestamp":1790657739603,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Efficient and safe mobilization of peripheral blood CD34\n                    <jats:sup>+<\/jats:sup>\n                    stem cells is essential for successful autologous stem cell transplantation (ASCT) in patients with lymphoid malignancies. However, current mobilization strategies are often limited by suboptimal yield, significant toxicity, or high cost. We conducted a prospective observational study including 59 patients with lymphoma or multiple myeloma undergoing ASCT. Patients received fractionated intermediate\u2010dose etoposide (175\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    twice on days 1 and 2) followed by granulocyte colony\u2010stimulating factor (G\u2010CSF, 10\u2009\u03bcg\/kg daily). Mobilization efficacy, safety profile, and subsequent transplantation outcomes were evaluated. Successful mobilization (\u2265\u20092\u2009\u00d7\u200910\n                    <jats:sup>6<\/jats:sup>\n                    CD34+ cells\/kg) was achieved in 96.6% of patients within three days of apheresis. The median CD34\n                    <jats:sup>+<\/jats:sup>\n                    cell yield was 5.35\u2009\u00d7\u200910\n                    <jats:sup>6<\/jats:sup>\n                    CD34+ cells\/kg on the first day. Notably, 61.0% and 49.2% of patients collected \u2265\u20094\u2009\u00d7\u200910\n                    <jats:sup>6<\/jats:sup>\n                    and \u2265\u20096\u2009\u00d7\u200910\n                    <jats:sup>6<\/jats:sup>\n                    CD34\n                    <jats:sup>+<\/jats:sup>\n                    cells\/kg on the first day, respectively. Despite frequent grade 3\u20134 cytopenias, clinically significant complications were limited, with febrile neutropenia occurring in 16.9% of patients and no treatment\u2010related mortality (TRM). All patients achieved neutrophil and platelet engraftment. Fractionated intermediate\u2010dose etoposide combined with G\u2010CSF achieved a high mobilization success rate, with most patients requiring a limited number of apheresis sessions and no TRM.\n                  <\/jats:p>","DOI":"10.1002\/jca.70183","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:12:59Z","timestamp":1790655179000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fractionated Intermediate\u2010Dose Etoposide Plus G\u2010\n                    <scp>CSF<\/scp>\n                    for Peripheral Blood Stem Cell Mobilization in Patients With Lymphoma and Multiple Myeloma Undergoing Autologous Stem Cell Transplantation: A Prospective Observational Study"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9106-9326","authenticated-orcid":false,"given":"Yoo Jin","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology, Ulsan University Hospital University of Ulsan College of Medicine  Ulsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hyuk","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Ulsan University Hospital University of Ulsan College of Medicine  Ulsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youjin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Ulsan University Hospital University of Ulsan College of Medicine  Ulsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Hun","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Ulsan University Hospital University of Ulsan College of Medicine  Ulsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun\u2010Ki","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Ulsan University Hospital University of Ulsan College of Medicine  Ulsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8744-5747","authenticated-orcid":false,"given":"HeeJung","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ulsan University Hospital University of Ulsan College of Medicine  Ulsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6014-7977","authenticated-orcid":false,"given":"Jae\u2010Cheol","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Ulsan University Hospital University of Ulsan College of Medicine  Ulsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/s41409-022-01691-w","article-title":"Indications for Haematopoietic Cell Transplantation for Haematological Diseases, Solid Tumours and Immune Disorders: Current Practice in Europe, 2022","volume":"57","author":"Snowden J. A.","year":"2022","journal-title":"Bone Marrow Transplantation"},{"key":"e_1_2_13_3_1","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1080\/10428190701843213","article-title":"Factors Affecting Autologous Peripheral Blood Stem Cell Collection in Patients With Relapsed or Refractory Diffuse Large Cell Lymphoma and Hodgkin Lymphoma: A Single Institution Result of 168 Patients","volume":"49","author":"Akhtar S.","year":"2008","journal-title":"Leukemia & Lymphoma"},{"key":"e_1_2_13_4_1","first-page":"937","article-title":"Factors Influencing Collection of Peripheral Blood Stem Cells in Patients With Multiple Myeloma","volume":"17","author":"Demirer T.","year":"1996","journal-title":"Bone Marrow Transplantation"},{"key":"e_1_2_13_5_1","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1080\/1042819031000067585","article-title":"Poor Mobilization of Peripheral Blood Stem Cells Is a Risk Factor for Worse Outcome in Lymphoma Patients Undergoing Autologous Stem Cell Transplantation","volume":"44","author":"Gordan L. N.","year":"2003","journal-title":"Leukemia & Lymphoma"},{"key":"e_1_2_13_6_1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00277-020-04376-w","article-title":"Comparison of the Efficiency, Safety, and Survival Outcomes in Two Stem Cell Mobilization Regimens With Cyclophosphamide Plus G\u2010CSF or G\u2010CSF Alone in Multiple Myeloma: A Meta\u2010Analysis","volume":"100","author":"Wang L.","year":"2021","journal-title":"Annals of Hematology"},{"key":"e_1_2_13_7_1","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/sj.bmt.1701791","article-title":"Successful Peripheral Blood Stem Cell Mobilization With Etoposide (VP\u201016) in Patients With Relapsed or Resistant Lymphoma Who Failed Cyclophosphamide Mobilization","volume":"23","author":"Reiser M.","year":"1999","journal-title":"Bone Marrow Transplantation"},{"key":"e_1_2_13_8_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12885-019-5285-1","article-title":"Optimal Chemo\u2010Mobilization for the Collection of Peripheral Blood Stem Cells in Patients With Multiple Myeloma","volume":"19","author":"Song G. Y.","year":"2019","journal-title":"BMC Cancer"},{"key":"e_1_2_13_9_1","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/bmt.2012.216","article-title":"Effectiveness of Etoposide Chemomobilization in Lymphoma Patients Undergoing Auto\u2010SCT","volume":"48","author":"Wood W. A.","year":"2013","journal-title":"Bone Marrow Transplantation"},{"key":"e_1_2_13_10_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.bbmt.2010.06.021","article-title":"Chemomobilization With Etoposide Is Highly Effective in Patients With Multiple Myeloma and Overcomes the Effects of Age and Prior Therapy","volume":"17","author":"Wood W. A.","year":"2011","journal-title":"Biology of Blood and Marrow Transplantation"},{"key":"e_1_2_13_11_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.transci.2021.103197","article-title":"Cyclophosphamide Plus Etoposide Is a Safe and Effective Mobilization Regimen in Patients With Multiple Myeloma","volume":"60","author":"Heider M.","year":"2021","journal-title":"Transfusion and Apheresis Science"},{"key":"e_1_2_13_12_1","doi-asserted-by":"crossref","first-page":"E27","DOI":"10.25011\/cim.v43i3.34643","article-title":"Effective Mobilization With Etoposide and Cyclophosphamide for Collection of Peripheral Blood Stem Cell in Patients With Multiple Myeloma","volume":"43","author":"Wang X.","year":"2020","journal-title":"Clinical and Investigative Medicine"},{"key":"e_1_2_13_13_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.bbmt.2013.10.012","article-title":"High\u2010Dose Etoposide Plus Granulocyte Colony\u2010Stimulating Factor as an Effective Chemomobilization Regimen for Autologous Stem Cell Transplantation in Patients With Non\u2010Hodgkin Lymphoma Previously Treated With CHOP\u2010Based Chemotherapy: A Study From the Consortium for Improving Survival of Lymphoma","volume":"20","author":"Hyun S. Y.","year":"2014","journal-title":"Biology of Blood and Marrow Transplantation"},{"key":"e_1_2_13_14_1","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/ejh.12266","article-title":"Chemomobilization With High\u2010Dose Etoposide and G\u2010CSF Results in Effective and Safe Stem Cell Collection in Heavily Pretreated Lymphoma Patients: Report From a Single Institution Study and Review","volume":"92","author":"Ozkan H. A.","year":"2014","journal-title":"European Journal of Haematology"},{"key":"e_1_2_13_15_1","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.1200\/JCO.2008.20.7209","article-title":"Phase III Prospective Randomized Double\u2010Blind Placebo\u2010Controlled Trial of Plerixafor Plus Granulocyte Colony\u2010Stimulating Factor Compared With Placebo Plus Granulocyte Colony\u2010Stimulating Factor for Autologous Stem\u2010Cell Mobilization and Transplantation for Patients With Non\u2010Hodgkin's Lymphoma","volume":"27","author":"DiPersio J. F.","year":"2009","journal-title":"Journal of Clinical Oncology"},{"key":"e_1_2_13_16_1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/bmt.2010.54","article-title":"Plerixafor Plus Granulocyte CSF Can Mobilize Hematopoietic Stem Cells From Multiple Myeloma and Lymphoma Patients Failing Previous Mobilization Attempts: EU Compassionate Use Data","volume":"46","author":"Duarte R. F.","year":"2011","journal-title":"Bone Marrow Transplantation"},{"key":"e_1_2_13_17_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/bmt.2009.119","article-title":"Safety and Preliminary Efficacy of Plerixafor (Mozobil) in Combination With Chemotherapy and G\u2010CSF: An Open\u2010Label, Multicenter, Exploratory Trial in Patients With Multiple Myeloma and Non\u2010Hodgkin's Lymphoma Undergoing Stem Cell Mobilization","volume":"45","author":"Dugan M. J.","year":"2010","journal-title":"Bone Marrow Transplantation"},{"key":"e_1_2_13_18_1","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/s41591-023-02273-z","article-title":"Motixafortide and G\u2010CSF to Mobilize Hematopoietic Stem Cells for Autologous Transplantation in Multiple Myeloma: A Randomized Phase 3 Trial","volume":"29","author":"Crees Z. D.","year":"2023","journal-title":"Nature Medicine"},{"key":"e_1_2_13_19_1","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1182\/blood.V85.8.2269.bloodjournal8582269","article-title":"Interleukin\u20108 Induces Rapid Mobilization of Hematopoietic Stem Cells With Radioprotective Capacity and Long\u2010Term Myelolymphoid Repopulating Ability","volume":"85","author":"Laterveer L.","year":"1995","journal-title":"Blood"},{"key":"e_1_2_13_20_1","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1186\/s12885-020-07102-x","article-title":"Etoposide\u2010Mediated Interleukin\u20108 Secretion From Bone Marrow Stromal Cells Induces Hematopoietic Stem Cell Mobilization","volume":"20","author":"Kang K. W.","year":"2020","journal-title":"BMC Cancer"},{"key":"e_1_2_13_21_1","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/jca.21734","article-title":"Single\u2010Dose Etoposide Is an Effective and Safe Protocol for Stem Cell Mobilization in Patients With Multiple Myeloma","volume":"34","author":"Park Y.","year":"2019","journal-title":"Journal of Clinical Apheresis"}],"container-title":["Journal of Clinical Apheresis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.70183","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jca.70183","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.70183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:13:03Z","timestamp":1790655183000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jca.70183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,28]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/jca.70183"],"URL":"https:\/\/doi.org\/10.1002\/jca.70183","archive":["Portico"],"relation":{},"ISSN":["0733-2459","1098-1101"],"issn-type":[{"value":"0733-2459","type":"print"},{"value":"1098-1101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,28]]},"assertion":[{"value":"2026-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70183"}}