{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:53:44Z","timestamp":1791258824715,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Selective plasma exchange (SePE) may reduce adverse events associated with fresh frozen plasma (FFP) use during pretransplant desensitization for ABO\u2010incompatible kidney transplantation. We conducted a single\u2010center retrospective cohort study of 75 patients who underwent ABO\u2010incompatible kidney transplantation between January 2020 and April 2024. Of these, 48 received SePE and 27 received conventional plasma exchange (CPE) with FFP. We compared antibody titers at transplantation, perioperative outcomes, and procedure\u2010related adverse events between the groups. Adverse events occurred in 5 patients (10.4%) in the SePE group and 17 patients (63.0%) in the CPE group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Anaphylactic shock occurred in no patients in the SePE group and 4 patients (14.8%) in the CPE group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.027). All patients in the SePE group and all but one patient in the CPE group achieved the prespecified preoperative antibody titer target of \u2264\u20091:32. Neither surgical operating time nor intraoperative blood loss differed significantly between the groups. In this cohort, SePE was associated with fewer procedure\u2010related adverse events than CPE with FFP while achieving the preoperative antibody titer target in all SePE\u2010treated patients.\n                  <\/jats:p>","DOI":"10.1002\/jca.70186","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:37:10Z","timestamp":1791257830000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Safety and Efficacy of Selective Plasma Exchange Versus Conventional Plasma Exchange in Pretransplant Desensitization of\n                    <scp>ABO<\/scp>\n                    \u2010Incompatible Kidney Transplantation"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4560-5230","authenticated-orcid":false,"given":"Takahiro","family":"Inoue","sequence":"first","affiliation":[{"name":"Department of Blood Purification Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2097-2662","authenticated-orcid":false,"given":"Hajime","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of Blood Purification Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Munakata","sequence":"additional","affiliation":[{"name":"Department of Blood Purification Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9691-9825","authenticated-orcid":false,"given":"Yuki","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of Blood Purification Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department of Blood Purification Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7309-0658","authenticated-orcid":false,"given":"Kohei","family":"Unagami","sequence":"additional","affiliation":[{"name":"Department of Organ Transplant Medicine Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0444-101X","authenticated-orcid":false,"given":"Junichi","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Department of Nephrology Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7370-4728","authenticated-orcid":false,"given":"Hideki","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Organ Transplant Medicine Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Organ Transplant Medicine Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0563-3320","authenticated-orcid":false,"given":"Norio","family":"Hanafusa","sequence":"additional","affiliation":[{"name":"Department of Blood Purification Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"issue":"5","key":"e_1_2_13_2_1","first-page":"243","article-title":"Therapeutic Plasma Exchange: Complications and Management","volume":"26","author":"Mokrzycki M. H.","year":"2011","journal-title":"Journal of Clinical Apheresis"},{"issue":"5","key":"e_1_2_13_3_1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/jca.20143","article-title":"Complications of Therapeutic Plasma Exchange: A Prospective Study of 1,727 Procedures","volume":"22","author":"Shemin D.","year":"2007","journal-title":"Journal of Clinical Apheresis"},{"issue":"3","key":"e_1_2_13_4_1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1600-6143.2008.02538.x","article-title":"Acute Antibody\u2010Mediated Rejection in Living ABO\u2010Incompatible Kidney Transplantation: Long\u2010Term Impact and Risk Factors","volume":"9","author":"Toki D.","year":"2009","journal-title":"American Journal of Transplantation"},{"issue":"5","key":"e_1_2_13_5_1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.transci.2017.08.010","article-title":"Selective Plasma Exchange","volume":"56","author":"Ohkubo A.","year":"2017","journal-title":"Transfusion and Apheresis Science"},{"issue":"1","key":"e_1_2_13_6_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-58436-2","article-title":"Selective Plasma Exchange in ABO\u2010Incompatible Kidney Transplantation: Comparison of Substitution With Albumin and Partial Substitution With Fresh Frozen Plasma","volume":"10","author":"Hanaoka A.","year":"2020","journal-title":"Scientific Reports"},{"issue":"1","key":"e_1_2_13_7_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s41100-019-0204-0","article-title":"Efficacy of Selective Plasma Exchange as Pre\u2010Transplant Apheresis in ABO\u2010Incompatible Kidney Transplantation","volume":"5","author":"Hanaoka A.","year":"2019","journal-title":"Renal Replacement Therapy"},{"key":"e_1_2_13_8_1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/1744-9987.12346","article-title":"Removal Characteristics of Immunoglobulin G Subclasses by Conventional Plasma Exchange and Selective Plasma Exchange","volume":"19","author":"Ohkubo A.","year":"2015","journal-title":"Therapeutic Apheresis and Dialysis"},{"key":"e_1_2_13_9_1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.transci.2013.06.004","article-title":"The Effect of Different Apheresis Modalities on Coagulation Factor XIII Level During Antibody Removal in ABO\u2010Blood Type Incompatible Living Related Renal Transplantation","volume":"49","author":"Hanafusa N.","year":"2013","journal-title":"Transfusion and Apheresis Science"},{"key":"e_1_2_13_10_1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1744-9987.2011.00930.x","article-title":"Theoretical Basis of Pathogenic Substance Removal During Plasmapheresis","volume":"15","author":"Hanafusa N.","year":"2011","journal-title":"Therapeutic Apheresis and Dialysis"},{"issue":"6","key":"e_1_2_13_11_1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/jca.21513","article-title":"Selective Plasma Exchange Can Reduce Auto\u2010Antibodies in Patients With Bullous Pemphigoid Without Affecting Factor XIII and Fibrinogen","volume":"32","author":"Nasu K.","year":"2017","journal-title":"Journal of Clinical Apheresis"},{"issue":"12","key":"e_1_2_13_12_1","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1097\/01.tp.0000296103.34735.b8","article-title":"Double\u2010Filtration Plasmapheresis","volume":"84","author":"Tanabe K.","year":"2007","journal-title":"Transplantation"},{"issue":"12","key":"e_1_2_13_13_1","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1097\/TP.0b013e3181726849","article-title":"ABO\u2010Incompatible Kidney Transplantation Using Antigen\u2010Specific Immunoadsorption and Rituximab: A 3\u2010Year Follow\u2010Up","volume":"85","author":"Genberg H.","year":"2008","journal-title":"Transplantation"},{"issue":"10","key":"e_1_2_13_14_1","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1097\/TP.0b013e31823360cf","article-title":"Antibody Removal Before ABO\u2010Incompatible Renal Transplantation: How Much Plasma Exchange Is Therapeutic?","volume":"92","author":"Lawrence C.","year":"2011","journal-title":"Transplantation"},{"issue":"2","key":"e_1_2_13_15_1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3109\/0886022X.2011.552149","article-title":"Comparison of Clinical Outcome Between High and Low Baseline Anti\u2010ABO Antibody Titers in ABO\u2010Incompatible Kidney Transplantation","volume":"33","author":"Chung B. H.","year":"2011","journal-title":"Renal Failure"},{"issue":"1","key":"e_1_2_13_16_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/tri.12412","article-title":"ABO\u2010Incompatible Kidney Transplant Recipients Have a Higher Bleeding Risk After Antigen\u2010Specific Immunoadsorption","volume":"28","author":"Weerd A. E.","year":"2015","journal-title":"Transplant International"},{"issue":"5","key":"e_1_2_13_17_1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/jca.21378","article-title":"Benefits of Fresh\u2010Frozen Plasma as a Replacement Fluid to Neutralize ABO Antibodies","volume":"30","author":"Won D. I.","year":"2015","journal-title":"Journal of Clinical Apheresis"},{"key":"e_1_2_13_18_1","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/1744-9987.12465","article-title":"Removal Dynamics of Immunoglobulin and Fibrinogen by Conventional Plasma Exchange, Selective Plasma Exchange, and a Combination of the Two","volume":"20","author":"Miyamoto S.","year":"2016","journal-title":"Therapeutic Apheresis and Dialysis"},{"key":"e_1_2_13_19_1","doi-asserted-by":"crossref","DOI":"10.1186\/s41100-024-00544-0","article-title":"Comparison of Estimated Blood Loss During Living Kidney Transplantation According to the Number of Double\u2010Filtration Plasmapheresis","volume":"10","author":"Yagisawa T.","year":"2024","journal-title":"Renal Replacement Therapy"}],"container-title":["Journal of Clinical Apheresis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.70186","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jca.70186","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.70186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:37:26Z","timestamp":1791257846000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jca.70186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/jca.70186"],"URL":"https:\/\/doi.org\/10.1002\/jca.70186","archive":["Portico"],"relation":{},"ISSN":["0733-2459","1098-1101"],"issn-type":[{"value":"0733-2459","type":"print"},{"value":"1098-1101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70186"}}