{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T07:38:09Z","timestamp":1793173089152,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Direct comparisons between centrifugal therapeutic plasma exchange (cTPE) and double\u2010filtration plasmapheresis (DFPP) remain scarce. We compared cTPE and DFPP in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), regarding clinical outcomes, biological effects, tolerability, session times and hospital costs. Lymphoapheresis was a prospective, single\u2010center, randomized, crossover ancillary study. At study entry, 5 patients with idiopathic CIDP on long\u2010term therapeutic plasmapheresis were randomized to start with either cTPE or DFPP, then undergo 6 alternating sessions, for 30 sessions (15 cTPE, 15 DFPP) in all. Two patients had central venous access (CVA), and 3 had peripheral (PVA). Target treated plasma volume was identical for all patients. Clinical outcomes, intraprocedural tolerance, session\u2010related biological changes, total session times, and procedure\u2010related costs were compared using within\u2010patient analyses and mixed\u2010effects models. All 5 patients were men, median age 62 [56\u201368] years. The median treated plasma volume was similar for cTPE and DFPP sessions (4500\u2009mL [4400\u20135000]). No difference was observed between modalities regarding short\u2010term clinical outcomes or adverse events. Total session time differed insignificantly between modalities, but was longer with PVA than with CVA (201 [189\u2013209] vs. 177 [163\u2013192] minutes;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01). Compared with DFPP, cTPE induced greater per\u2010session reductions in platelets, fibrinogen, prothrombin time, and IgG but not in IgM or Hb. Albumin use was markedly higher with cTPE than with DFPP (180\u2009g vs. 20\u2009g per session). By contrast, weight gain was greater with DFPP than with cTPE (1.0 [0.5\u20131.5] vs. 0.4 [0.0\u20130.5] kg;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04). Estimated hospital costs per session were higher with DFPP than with cTPE using HSA rather than FFP as fluid replacement, based on French blood product costs. The cost of DFPP is mainly due to material and platform costs and cTPE to blood products and staff requirements. In chronically treated CIDP patients, cTPE and DFPP showed similar short\u2010term clinical efficacy and safety. Total session time depended on vascular access rather than the plasmapheresis modality. The cost of DFPP is mainly due to material and platform costs and cTPE to blood products and staff requirements.\n                  <\/jats:p>","DOI":"10.1002\/jca.70191","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:18:46Z","timestamp":1791429526000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Centrifugal Plasma Exchange Versus Double\u2010Filtration Plasmapheresis in Chronic\n                    <scp>CIDP<\/scp>\n                    : A Randomized Crossover Study Comparing Clinical Outcomes, Biological Effects, Procedure Times, and Costs\u2014The Lymphoapheresis Study"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3127-1415","authenticated-orcid":false,"given":"O.","family":"Moranne","sequence":"first","affiliation":[{"name":"Service N\u00e9phrologie\u2010Dialyse\u2010Aph\u00e9r\u00e8se, Hopital universitaire de Nimes  Nimes France"},{"name":"Institut Desbrest d'\u00c9pid\u00e9miologie et de Sant\u00e9 Publique (IDESP), University of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Chkair","sequence":"additional","affiliation":[{"name":"Institut Desbrest d'\u00c9pid\u00e9miologie et de Sant\u00e9 Publique (IDESP), University of Montpellier  Montpellier France"},{"name":"Department of Biostatistics, Clinical Epidemiology, Public Health and Innovation in Methodology (BESPIM), Hopital universitaire de Nimes University of Montpellier  N\u00eemes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3713-6131","authenticated-orcid":false,"given":"P.","family":"Ahmadapoor","sequence":"additional","affiliation":[{"name":"Service N\u00e9phrologie\u2010Dialyse\u2010Aph\u00e9r\u00e8se, Hopital universitaire de Nimes  Nimes 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