{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T05:44:51Z","timestamp":1791783891735,"version":"4.3.4"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma (HCC) and liver failure. The double plasma molecular adsorption system (DPMAS) reduces bilirubin and may create a therapeutic window for anti\u2010tumor therapy in HCC patients. Two plasma separation techniques are used: membrane\u2010based (MBS\u2010DPMAS) and centrifugal (CPS\u2010DPMAS), but no study has compared them specifically in HCC patients with acute\u2010on\u2010chronic liver failure (ACLF). This retrospective study included 203 HBV\u2010related HCC patients who received DPMAS without plasma exchange (93 MBS\u2010DPMAS, 110 CPS\u2010DPMAS), with citrate anticoagulation used in all cases. Bilirubin, liver enzymes, INR, and platelet count were compared between groups and before versus after treatment. Baseline characteristics were comparable. CPS\u2010DPMAS showed superior bilirubin reduction (TBIL: 184.60 vs. 220.05\u2009\u03bcmol\/L,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002; DBIL: 156.04 vs. 183.55\u2009\u03bcmol\/L,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004), whereas platelet count was significantly higher after MBS\u2010DPMAS than after CPS\u2010DPMAS (135.35 vs. 106.32\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.012). Both modalities decreased INR transiently, and only MBS\u2010DPMAS significantly reduced ALT, AST, and creatinine. In conclusion, both techniques effectively reduce bilirubin and decrease INR, but CPS\u2010DPMAS offers better bilirubin clearance while MBS\u2010DPMAS provides better platelet protection, suggesting that technique selection should be individualized.\n                  <\/jats:p>","DOI":"10.1002\/jca.70192","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:52:15Z","timestamp":1791780735000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Single Center Retrospective Study: Efficacy and Platelet Preservation of Double Plasma Molecular Adsorption System Therapy by Membrane Separation Versus Centrifugal Separation in Acute\u2010on\u2010Chronic Liver Failure Patients With Hepatocellular Carcinoma"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7275-188X","authenticated-orcid":false,"given":"Guozhen","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Intensive Care Medicine Tianjin Cancer Hospital Airport Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Tianjin Cancer Hospital Airport Hospital  Tianjin China"},{"name":"Department of Radiotherapy Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Tianjin Cancer Hospital Airport Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0982-5969","authenticated-orcid":false,"given":"QingPei","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Tianjin Cancer Hospital Airport Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BoWei","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Tianjin Cancer Hospital Airport Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7575-3339","authenticated-orcid":false,"given":"YueYang","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Tianjin Cancer Hospital Airport Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HaoXin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Tianjin Cancer Hospital Airport Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Tianjin Cancer Hospital Airport Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Tianjin Cancer Hospital Airport Hospital  Tianjin China"},{"name":"Department of Intensive Care Medicine Tianjin Medical University Cancer Institute and Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,11]]},"reference":[{"issue":"4","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/jvh.13800","article-title":"Clinical and Patient\u2010Reported Outcome Profile of Patients With Hepatitis B Viral Infection From the Global Liver Registry","volume":"30","author":"Younossi Z. M.","year":"2023","journal-title":"Journal of Viral Hepatitis"},{"key":"e_1_2_10_3_1","article-title":"A Lower HCC Incidence in Chronic HBV\u2010Infected Patients Recovered From Acute\u2010On\u2010Chronic Liver Failure: A Prospective Cohort Study","volume":"2022","author":"Yin J.","year":"2022","journal-title":"Journal of Oncology"},{"issue":"4","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1007\/s12029-021-00745-4","article-title":"Hepatitis B Before and After Hepatocellular Carcinoma","volume":"52","author":"Harputluoglu M.","year":"2021","journal-title":"Journal of Gastrointestinal Cancer"},{"issue":"3","key":"e_1_2_10_5_1","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung H.","year":"2021","journal-title":"CA: A Cancer Journal for Clinicians"},{"issue":"3","key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1007\/s10620-022-07565-x","article-title":"Clinical Course and Outcomes of Patients With Nonalcoholic Fatty Liver Disease\u2010Related Hepatocellular Cancer (NAFLD\u2010HCC)","volume":"68","author":"Chu J.","year":"2023","journal-title":"Digestive Diseases and Sciences"},{"issue":"1","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.bpg.2012.01.001","article-title":"Stem Cells in Liver Failure","volume":"26","author":"Russo F. 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Q.","year":"2024","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"issue":"2","key":"e_1_2_10_15_1","first-page":"180","article-title":"Application of Double Plasma Molecular Adsorption System in Children With Acute Liver Failure","volume":"23","author":"He J.","year":"2021","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"issue":"6","key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/jca.21936","article-title":"Membrane\u2010Based Therapeutic Plasma Exchange: Hemodynamics and Operational Characteristics Leading to Procedure Failure","volume":"36","author":"Elali I.","year":"2021","journal-title":"Journal of Clinical Apheresis"},{"issue":"12","key":"e_1_2_10_17_1","first-page":"1109","article-title":"Comparison of the Effectiveness and Safety Profile of Centrifugal and Membrane Plasma Separation in Artificial Liver Therapy With a Dual Plasma Molecular Adsorption System","volume":"32","author":"Li Y.","year":"2024","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"issue":"1","key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s11255-015-1137-3","article-title":"Membrane Versus Centrifuge\u2010Based Therapeutic Plasma Exchange: A Randomized Prospective Crossover Study","volume":"48","author":"Hafer C.","year":"2016","journal-title":"International Urology and Nephrology"}],"container-title":["Journal of Clinical Apheresis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.70192","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jca.70192","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.70192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:52:42Z","timestamp":1791780762000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jca.70192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/jca.70192"],"URL":"https:\/\/doi.org\/10.1002\/jca.70192","archive":["Portico"],"relation":{},"ISSN":["0733-2459","1098-1101"],"issn-type":[{"value":"0733-2459","type":"print"},{"value":"1098-1101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70192"}}