{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T07:38:05Z","timestamp":1793173085587,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Although apheresis techniques in children are well established, published experience with very low\u2010weight children is limited. We reviewed 68 procedures performed in 19 children weighing less than 7\u2009kg, including hematopoietic progenitor and T\u2010cell collections and plasmapheresis. With significant modifications of standard techniques, all but one procedure was successfully and safely completed without serious citrate toxicity. Access was a major challenge. For plasmapheresis, the mean plasma volume removed was 1.2\u2009\u00d7\u2009total plasma volume, but the mean total blood processed was 1.74\u2009\u00d7\u2009total blood volume (TBV). For collections, the mean number of whole blood volumes processed was 4.1\u2009\u00d7\u2009TBV. For T cell collections, the median CD3+ yield was 243.6\u2009\u00d7\u200910\n                    <jats:sup>6<\/jats:sup>\n                    \/kg. For HPC collections, the median CD34+ cell yield was 14.8\u2009\u00d7\u200910\n                    <jats:sup>6<\/jats:sup>\n                    \/kg. Mean durations for collections and plasmapheresis were 247.00 and 120.67\u2009min, respectively. Of the CBC parameters, only platelet count was significantly lower after collections.\n                  <\/jats:p>","DOI":"10.1002\/jca.70195","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:46:09Z","timestamp":1792039569000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Apheresis in Children of Weight Under 7\u2009kg\u2014A Single Center Experience"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8172-1042","authenticated-orcid":false,"given":"Phassawan","family":"Rungsiprakarn","sequence":"first","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Bryan E.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Apheresis Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie E.","family":"Rintoul","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0016-078X","authenticated-orcid":false,"given":"K. 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