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In this report, we show that TSA suppresses the expression of the T cell receptor \u03b6 chain gene, whereas, it upregulates the expression if its homologous gene Fc\u03b5 receptor I \u03b3 chain. These effects are associated with decreased intracytoplasmic\u2010free calcium responses and altered tyrosine phosphorylation pattern of cytosolic proteins. Along with these effects, we report that TSA suppresses the expression of the interleukin\u20102 gene. The effects of TSA on human T cells are predominantly immunosuppressive and reminiscent of the signaling aberrations that have been described in patients with systemic lupus erythematosus. J. Cell. Biochem. 85: 459\u2013469, 2002. 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