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The functionality of Notch signalling was tested using <jats:italic>HES1<\/jats:italic> gene activation. We show that Notch signalling is differentially regulated in T\u2010acute lymphoblastic leukaemia (ALL) and B\u2010lymphoma cells. The Notch pathway is intact in a majority of B\u2010lymphoma cell lines, but EBNA2, which mimics notch function, can occasionally activate the pathway. In contrast, the Notch pathway is constitutively active in T\u2010ALL. This is the first demonstration of a distinction between B\u2010lymphomas and T\u2010cell leukaemias in the functioning of the Notch\u2010signalling pathway. This might be related to their pathogenesis. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcb.10383","type":"journal-article","created":{"date-parts":[[2003,1,17]],"date-time":"2003-01-17T16:46:53Z","timestamp":1042822013000},"page":"569-577","source":"Crossref","is-referenced-by-count":20,"title":["Differential regulation of Notch signal transduction in leukaemia and lymphoma cells in culture"],"prefix":"10.1002","volume":"88","author":[{"given":"Raffaella","family":"Chiaramonte","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Calzavara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Balordi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Sabbadini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Capello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Gaidano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Serra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Comi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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