{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T22:58:46Z","timestamp":1772751526831,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,8,21]],"date-time":"2001-08-21T00:00:00Z","timestamp":998352000000},"content-version":"vor","delay-in-days":232,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The AP\u20102 transcription factor plays a pivotal role in regulating the expression of several genes involved in tumor growth and progression of melanoma. We determined, by Western blot, variation in the level of expression of AP\u20102 and three of its downstream targets, c\u2010kit, E\u2010cadherin, and p21 in several human melanoma cell lines and, by immunohistochemistry, in a group of 99 histological samples including benign and malignat melanocytic lesions. A significant negative correlation between AP\u20102 expression level and tumor thickness was found. Moreover, AP\u20102 expression was positively associated with E\u2010cadherin and c\u2010kit expression. In contrast, there was a significant negative association between AP\u20102 and p21 expression levels. These findings suggest that p21 is independent of AP\u20102 transactivator function during the latest phases of melanoma progression. Finally, AP\u20102, c\u2010kit, E\u2010cadherin, and p21 expression levels did not show to be able to distinguish between dysplastic nevi and nevi without dysplasia. We conclude that changes in the expression of these proteins are involved in the later phases of melanoma progression, and may be responsible for the transition from local invasive melanoma to metastasis. J. Cell. Biochem. 83: 364\u2013372, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcb.1235","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T19:53:55Z","timestamp":1030305235000},"page":"364-372","source":"Crossref","is-referenced-by-count":45,"title":["Expression of AP\u20102 transcription factor and of its downstream target genes c\u2010kit, E\u2010cadherin and p21 in human cutaneous melanoma"],"prefix":"10.1002","volume":"83","author":[{"given":"Alfonso","family":"Baldi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Santini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tullio","family":"Battista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Dragonetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"Ferranti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommasangelo","family":"Petitti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela 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