{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:30Z","timestamp":1786977990203,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,8,22]],"date-time":"2001-08-22T00:00:00Z","timestamp":998438400000},"content-version":"vor","delay-in-days":233,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"DGICYT","award":["PB95-1060"],"award-info":[{"award-number":["PB95-1060"]}]},{"name":"DGICYT","award":["PB98-1565"],"award-info":[{"award-number":["PB98-1565"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The Syrian hamster Harderian gland (HG) is an organ continually exposed to oxidative stress caused by high concentrations of porphyric metabolites. According to previous studies, melatonin, which is rhythmically secreted by the pineal gland and tonically produced by the HG, antagonizes the oxidative damage. HGs exhibit a strong gender\u2010dependent correlation between porphyrins, melatonin, and histological appearance. In HGs of both sexes, we have investigated effects of a single gene defect in the circadian clock system (tau mutation) causing a shortened free\u2010running period and an advanced maximum of circulating melatonin. Comparisons were made with wild\u2010type animals, one group of which received daily pharmacological injections of melatonin in late photophase. Changes were observed in histological characteristics, porphyrin content, antioxidant enzyme activities, and damage of proteins and lipids. HGs of tau hamsters showed morphological changes which can be partially interpreted in terms of increased damage. Additionally, tau females exhibited a many\u2010fold augmentation in the percentage of so\u2010called type II cells, which are otherwise typical for the male glands. In tau hamsters of both sexes, major antioxidative enzyme activities (superoxide dismutase, glutathione reductase, and catalase) were markedly enhanced, a presumably compensatory response to increased oxidative stress. Higher oxidative damage in tau HGs was directly demonstrable by a many\u2010fold increase in protein carbonyl. Rises in antioxidative enzymes were also observed upon injections of melatonin; this was, however, not accompanied by changes in protein carbonyl, so that enzyme inductions by the hormone should be understood as protective actions. Our data are not only in accordance with findings on protective effects by melatonin, but also with our earlier observation made in\n                    <jats:italic>Drosophila<\/jats:italic>\n                    that perturbations in the circadian system lead to increased oxidative stress. J. Cell. Biochem. 83: 426\u2013434, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/jcb.1240","type":"journal-article","created":{"date-parts":[[2004,11,14]],"date-time":"2004-11-14T16:31:04Z","timestamp":1100449864000},"page":"426-434","source":"Crossref","is-referenced-by-count":16,"title":["Effects of the circadian mutation \u2018tau\u2019 on the Harderian glands of Syrian hamsters"],"prefix":"10.1002","volume":"83","author":[{"given":"Ana","family":"Coto\u2010Montes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Tom\u00e1s\u2010Zapico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda 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