{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T18:41:14Z","timestamp":1704220874743},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,3,10]],"date-time":"2004-03-10T00:00:00Z","timestamp":1078876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2004,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We explored the feasibility of studying nuclear matrix protein (NMP) expressions of the hepatocytes in normal and cirrhotic rat livers with liver regeneration after partial hepatectomy. Sixteen Wistar healthy rats were studied with experimental liver regeneration and\/or liver cirrhosis. Two\u2010dimensional (2\u2010D) gel electrophoresis was used to generate these NMP compositions from these rat liver samples. Several antibodies against cytokeratin, vimentin, actin, B23, HNF4alpha, and heat shock protein 70 were used for identification by Western blot. Totally, 41 strongly stained protein spots were characterized on the 2\u2010D gels. Thirty\u2010four protein spots were detected in all of these rat livers, of which, cytokeratin, vimentin, actin, HNF4alpha, and heat shock protein 70 were identified. B23 was detected in the regenerated livers. Three protein spots (s33, s34, and s35) were detectable only in NMP preparation extracted from the regenerating rat livers after hepatectomy. Another three protein spots (s36, s37, and s38) were detectable only in NMP preparation extracted from thioacetamide\u2010induced cirrhotic rat livers. Under these conditions including experimental liver regeneration and\/or liver cirrhosis, Over thirty higher abundance NMPs of hepatocytes were consistently expressed and considered as common and basic NMPs. Some of the NMPs are specific for liver regeneration and may play a critical role in cell proliferation and cell cycle, and some are specific for liver cirrhosis. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcb.20034","type":"journal-article","created":{"date-parts":[[2004,3,24]],"date-time":"2004-03-24T08:02:47Z","timestamp":1080115367000},"page":"1269-1279","source":"Crossref","is-referenced-by-count":1,"title":["Nuclear matrix protein expressions in hepatocytes of normal and cirrhotic rat livers under normal and regenerating conditions"],"prefix":"10.1002","volume":"91","author":[{"given":"Jing\u2010Ping","family":"Yun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Choong\u2010Tsek","family":"Liew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eng Ching","family":"Chew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Yu","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul Bo San","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yam Hin","family":"Fai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.K. Richard","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei\u2010Lin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Xiao","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han\u2010Liang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan Yee","family":"Lau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,3,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150121110"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.11501601324"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(199608)62:2<223::AID-JCB10>3.0.CO;2-M"},{"key":"e_1_2_6_5_1","first-page":"3430","article-title":"Identification of the major protein adduct formed in rat liver after thioacetamide administration","volume":"41","author":"Dyroff MC","year":"1981","journal-title":"Cancer Res"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.1.121"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(19990801)74:2<145::AID-JCB1>3.0.CO;2-#"},{"issue":"7","key":"e_1_2_6_8_1","first-page":"1690","article-title":"Bladder cancer\u2010associated nuclear matrix proteins","volume":"56","author":"Getzenberg RH","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_6_9_1","first-page":"186","article-title":"Experimental pathology of the liver. I. Restoration of the liver of the white rat following partial surgical removal","volume":"12","author":"Higgin GM","year":"1931","journal-title":"Arch Pathol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9604"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290077"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.5.1913"},{"issue":"14","key":"e_1_2_6_13_1","first-page":"3394","article-title":"Nuclear matrix proteins in normal and breast cancer cells","volume":"53","author":"Khanuja PS","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150181138"},{"issue":"301","key":"e_1_2_6_15_1","first-page":"103","article-title":"Thioacetamide\u2010stimulated expression of non\u2010histone protein","volume":"75","author":"Krajewska WM","year":"1993","journal-title":"Cytobios"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(199608)62:2<275::AID-JCB15>3.0.CO;2-K"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(199704)65:1<42::AID-JCB5>3.0.CO;2-Z"},{"issue":"4","key":"e_1_2_6_18_1","first-page":"641","article-title":"Active DNA topoisomerase II with minimum molecular mass from regenerating rat liver","volume":"32","author":"Park SH","year":"1994","journal-title":"Biochem Mol Biol Int"},{"issue":"4","key":"e_1_2_6_19_1","first-page":"744","article-title":"Nuclear matrix protein patterns in human benign prostatic hyperplasia and prostate cancer","volume":"53","author":"Partin AW","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.12.5251"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150130190"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/18.5.935"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.11501601323"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)39383-4"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.86.1.173"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1996.0083"},{"issue":"1","key":"e_1_2_6_27_1","first-page":"209","article-title":"Effect of glucocorticoid hormone on nuclear matrix in cervical cancer cells in vitro","volume":"18","author":"Yam HF","year":"1998","journal-title":"Anticancer Res"},{"issue":"1","key":"e_1_2_6_28_1","first-page":"343","article-title":"The association of HPV 16 DNA with specific nuclear matrix proteins of normal and cervical carcinoma cell","volume":"17","author":"Yang L","year":"1997","journal-title":"Anticancer Res"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2000.01574.x"},{"issue":"14","key":"e_1_2_6_30_1","first-page":"974","article-title":"Expression and relocation of B23 in the process of rat liver cell hyperplasia and liver regeneration","volume":"82","author":"Yun JP","year":"2002","journal-title":"Natl Med J China"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.10706"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.20034","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.20034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T15:00:48Z","timestamp":1696863648000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.20034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3,10]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,4,15]]}},"alternative-id":["10.1002\/jcb.20034"],"URL":"https:\/\/doi.org\/10.1002\/jcb.20034","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,3,10]]}}}