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Its manifestations are the dynamic ongoing production of chromosomal rearrangements, mutations, gene amplifications, transformation, microsatellite instability, and\/or cell killing. In this prospectus, we present the hypothesis that cellular exposure to ionizing radiation can result in the secretion of soluble factors by irradiated cells and\/or their progeny, and that these factors can elicit responses in other cells thereby initiating and perpetuating ongoing genomic instability. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcb.20149","type":"journal-article","created":{"date-parts":[[2004,6,14]],"date-time":"2004-06-14T21:01:11Z","timestamp":1087246871000},"page":"1013-1019","source":"Crossref","is-referenced-by-count":33,"title":["Radiation\u2010induced genomic instability: A role for secreted soluble factors in communicating the radiation response to non\u2010irradiated cells"],"prefix":"10.1002","volume":"92","author":[{"given":"Marianne B.","family":"Sowa Resat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William 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