{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T05:36:00Z","timestamp":1697607360423},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,8,11]],"date-time":"2004-08-11T00:00:00Z","timestamp":1092182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The native parathyroid hormone (PTH) and several of its N\u2010terminal adenylyl cyclase\u2010activating fragments and their analogs have become the star stimulators of bone growth for treating osteoporosis, accelerating fracture healing, and strengthening the anchorage of prosthetic bone implants and one of them (Lilly's Forteo\u2122\u2014recombinant hPTH\u2010(1\u201034) has recently arrived in the clinic. But something entirely different has been lurking in the background\u2014the ability of the adenylyl cyclase stimulating hPTH\u2010(1\u201034) to calm hyperproliferating keratinocytes and reduce psoriatic lesions. By contrast PTH\u2010(7\u201034) which cannot stimulate adenylyl cyclase actually stimulates keratinocyte proliferation. Normal keratinocytes make PTHrP after they lift off the basal lamina and have stopped cycling. But they have an unconventional PTH\/PTHrP receptorr which is not coupled to adenylyl cyclase. Psoriatic keratinocytes do not make PTHrP and have only a broken\u2010down, proliferation\u2010limiting terminal differentiation\u2010driving Notch\u2013Notch ligand mechanism. Putting these and other facts together produces a possible picture of an exogenously applied adenylyl cyclase\u2010activating PTH pinch hitting for the missing PTHrP and restoring normal keratinocyte proliferative activity epidermal structure by stimulating dermal fibroblasts which do have the conventional adenylyl cyclasse\u2010linked PTHR1 and in response directly or indirectly restore the overlying basal keratinocytes' Notch\u2013Notch ligand terminal differentiation\u2010driving mechanism and consequently a normal epidermal structure. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcb.20216","type":"journal-article","created":{"date-parts":[[2004,8,11]],"date-time":"2004-08-11T15:20:33Z","timestamp":1092237633000},"page":"251-256","source":"Crossref","is-referenced-by-count":7,"title":["Taming psoriatic keratinocytes\u2014PTHs' uses go up another notch"],"prefix":"10.1002","volume":"93","author":[{"given":"James F.","family":"Whitfield","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,8,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-003-0093-6"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.21.4287"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02040"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-9256-7"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/43.1.7822764"},{"key":"e_1_2_5_7_1","first-page":"S248","article-title":"RT\u2010PCR identification of PTHrp, PTH\/PTHrp receptor mRNAs during the steps of differentiation pathways of rat newborn keratinocytes: A putative autocrine role of PTHrp","volume":"23","author":"Errazahi A","year":"1998","journal-title":"Bone"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12313466"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.130.1.449"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.17.8014"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05437.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.130.1.1727720"},{"key":"e_1_2_5_13_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2340\/00015555728183","article-title":"Parathyroid hormone\u2010related protein is localized in the granular layer of normal skin and in the dermal infiltrates of mycosis fungoides but is absent in psoriatic lesions","volume":"72","author":"Juhlin L","year":"1992","journal-title":"Acta Derm Venereol (Stockh)"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12954-6"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00451-6"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2002.110403.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1991.01680010067010"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2000.009005359.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401036"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1099"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(04)00098-X"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.136.7.7789327"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000109416"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.13.3427"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12294690"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02259.x"},{"key":"e_1_2_5_27_1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1302\/0301-620X.83B3.0830437","article-title":"Implant fixation enhanced by intermittent treatment with parathyroid hormone","volume":"83","author":"Skripitz R","year":"2000","journal-title":"J Bone Joint Surg [Br]"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-2-7"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-003-0006-7"},{"key":"e_1_2_5_30_1","unstructured":"WhitfieldJF.2004.Growing Bone. 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