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There is limited data available on the interaction between specific T\u2010cell transcription factor GATA3 and Tax. Implications for the significance of GATA3 in T\u2010cell development and function, T helper2 (Th2) differentiation, and a role of GATA3 during the immune response have been reported. To determine the effect of the Tax protein on <jats:italic>GATA3<\/jats:italic> gene expression, we investigated the interaction between this protein and the GATA3 promoter and repressor regions. Results demonstrated an interaction between Tax and the GATA3 promoter via the transcription factor Sp1 and a role for Tax in the negative regulation of GATA3 expression, through its interaction with the repressor ZEB. This interaction may be involved in the pathophysiology of adult T\u2010cell leukemia\/lymphoma (ATL) and tropical spastic paraparesis\/HTLV\u2010I\u2010associated myelopathy (TSP\/HAM). \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcb.20290","type":"journal-article","created":{"date-parts":[[2004,10,14]],"date-time":"2004-10-14T22:00:35Z","timestamp":1097791235000},"page":"1178-1187","source":"Crossref","is-referenced-by-count":7,"title":["Regulation of the GATA3 promoter by human T\u2010cell lymphotropic virus type I Tax protein"],"prefix":"10.1002","volume":"93","author":[{"given":"Simone Cristina Olenscki","family":"Gilli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tereza Sueko Ide","family":"Salles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara Teresinha 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