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Cluster analysis identified several groups of genes with dynamic temporal expression patterns and stage\u2010specific functions. The immediate\u2010response genes are highlighted by binding activity, transporter activity, and energy derivation. We consider these activities as critical signals for initiation of fracture healing. The continuously increased genes are characterized by those directly involved in bone repair, thus, representing bone specific forefront workers. The constantly upregulated genes tend to regulate general cell growth and are enriched with genes that are involved in tumorigenesis, suggesting common pathways between two processes. The constantly downregulated genes predominantly involve immune response, the significance of which remains for further investigation. Knowledge acquired through this analysis of transcriptional activities at the early stage of bone healing will contribute to our understanding of fracture repair and bone\u2010related pathological conditions. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcb.20373","type":"journal-article","created":{"date-parts":[[2005,3,10]],"date-time":"2005-03-10T17:21:35Z","timestamp":1110475295000},"page":"189-205","source":"Crossref","is-referenced-by-count":31,"title":["Early signals for fracture healing"],"prefix":"10.1002","volume":"95","author":[{"given":"Xinmin","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Quigg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James 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