{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T17:51:26Z","timestamp":1721584286716},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,8,8]],"date-time":"2005-08-08T00:00:00Z","timestamp":1123459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2005,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The management of malignant cutaneous melanoma is problematic. Current clinical prognostic factors do not adequately predict disease recurrence and overall survival in a significant subset of patients. Adjuvant therapies for melanoma are notoriously toxic and associated with significant morbidity. Furthermore, it has been difficult to predict which patients will respond best to these treatments, if at all. DNA and RNA biomarkers have been developed to help overcome these problems. Biomarkers have been shown to upstage patients with melanoma, but are the assays sensitive and specific enough for clinical use as predictors of disease outcome or treatment response? We review our experience with DNA and RNA biomarkers in terms of their prognostic and predictive capabilities in malignant melanoma and outline their likely role in the future of melanoma staging, surveillance, and treatment. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcb.20556","type":"journal-article","created":{"date-parts":[[2005,8,8]],"date-time":"2005-08-08T20:18:10Z","timestamp":1123532290000},"page":"473-483","source":"Crossref","is-referenced-by-count":11,"title":["Molecular markers in malignant cutaneous melanoma: Gift horse or one\u2010trick pony?"],"prefix":"10.1002","volume":"96","author":[{"given":"Steve R.","family":"Martinez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dave S.B.","family":"Hoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,8,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.54.3.131"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.131.4.443"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-200204000-00007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.10.3238"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12371713"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.37.9.653"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.5.1760"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00766"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980115)82:2<317::AID-CNCR10>3.0.CO;2-1"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00131.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1994.48"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1995.293"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-0957"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2932"},{"key":"e_1_2_9_16_1","first-page":"1567","article-title":"Plasma DNA microsatellites as tumor\u2010specific markers and indicators of tumor progression in melanoma patients","volume":"59","author":"Fujiwara Y","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.6.2253"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.8.2818"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870120211"},{"key":"e_1_2_9_20_1","first-page":"1361","article-title":"Loss of heterozygosity and homozygous deletions on 9p21\u201022 in melanoma","volume":"9","author":"Holland EA","year":"1994","journal-title":"Oncogene"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.8.2109"},{"key":"e_1_2_9_22_1","first-page":"2253","article-title":"Molecular markers in blood as surrogate prognostic indicators of melanoma recurrence","volume":"60","author":"Hoon DS","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207505"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0994-15"},{"key":"e_1_2_9_25_1","first-page":"1649","article-title":"Chromosome 9 deletion in sporadic and familial melanomas in vivo","volume":"9","author":"Isshiki K","year":"1994","journal-title":"Oncogene"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg816"},{"key":"e_1_2_9_27_1","unstructured":"KoyanagiK KuoC MoriT NakagawaT UenoH LoricoAR HsuehE O'DaySJ HonDSB.2005.Quantitative detection of circulating melanoma cells in peripheral blood in melanoma patients using multimarker real time RT\u2010PCR. 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