{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T22:46:17Z","timestamp":1772145977124,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,9,26]],"date-time":"2005-09-26T00:00:00Z","timestamp":1127692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The roles of age and prolactin (PRL) in regulating glucocorticoid secretion in diestrous rats were investigated. Adrenal zona fasciculata\u2010reticularis (ZFR) cells from young, adult, middle (mid)\u2010aged, and old female rats were isolated. Estrous cycle stage was determined by light microscopy after vaginal smears. Blood samples were collected from right jugular vein at 0, 30, 60, and 120 min after challenge with adrenocorticotropin (ACTH). During the diestrous phase, plasma levels of estradiol and progesterone were lower in mid\u2010aged and old rats than in either young or adult rats. Age\u2010dependent increases of the basal levels of plasma PRL and corticosterone were observed. No difference of ACTH\u2010increased plasma concentrations of corticosterone was observed among young, adult, mid\u2010aged, and old rats. Aging increased the basal, ACTH\u2010, PRL\u2010, forskolin (an adenylate cyclase activator)\u2010, and 3\u2010isobutyl\u2010l\u2010methylxanthine (IBMX, a non\u2010selective phosphodiesterase inhibitor)\u2010stimulated release of corticosterone and production of adenosine 3\u2032, 5\u2032\u2010cyclic monophosphate (cAMP) in ZFR cells. However, the 8\u2010Br\u2010cAMP (a membrane\u2010permeable cAMP)\u2010stimulated release of corticosterone was not affected by age. Taken together, these data indicated that aging increased corticosterone secretion in female rats during diestrous phase, which is in part due to an increase in cAMP accumulation. In conclusion, aging and PRL play a stimulatory role in the co\u2010regulation of corticosterone secretion. J. Cell. Biochem. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcb.20576","type":"journal-article","created":{"date-parts":[[2005,9,26]],"date-time":"2005-09-26T22:19:24Z","timestamp":1127773164000},"page":"351-358","source":"Crossref","is-referenced-by-count":16,"title":["Effect of aging on corticosterone secretion in diestrous rats"],"prefix":"10.1002","volume":"97","author":[{"given":"Ming\u2010Jae","family":"Lo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei\u2010Mei","family":"Kau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulus 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