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Here we demonstrate that transient overexpression of the short splice variant 3 conferred \u03b1\u2010LTX induced secretion to hamster insulinoma (HIT\u201015) cells. In contrast, the long splice variant 2 containing four additional extracellular fibronectin\u2010III domains was inactive in secretion or in a single cell assay. Toxin\u2010sensitive (MIN6) and toxin\u2010insensitive (HIT\u2010T15) insulinoma cell lines as well as PC12 cells expressed similar amounts of endogenous short RPTP\u03c3 splice variant suggesting that this receptor does not play a role for toxin\u2010sensitivity. J. Cell. Biochem. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcb.20871","type":"journal-article","created":{"date-parts":[[2006,3,21]],"date-time":"2006-03-21T16:46:27Z","timestamp":1142959587000},"page":"1552-1559","source":"Crossref","is-referenced-by-count":10,"title":["Splice variant 3, but not 2 of receptor protein\u2010tyrosine phosphatase \u03c3 can mediate stimulation of insulin\u2010secretion by 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