{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:28:19Z","timestamp":1792704499346,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During the ageing process in rats hypercholesterolemia occurs in concert with full activation, lowered degradation rate and an unchanged level of the rate limiting cholesterol biosynthesis enzyme, 3\u2010hydroxy\u20103\u2010methylglutaryl coenzyme A reductase (HMG\u2010CoAR). The molecular bases of the HMG\u2010CoAR unchanged level and lowered degradation rate in aged rats is not clear. In fact no data are available during ageing, on transcription and degradation of HMG\u2010CoAR, so well defined in adult animal. So, aim of this work was to measure mRNA levels of the enzyme and the level of the proteins of the regulatory complex responsible of the cholesterol metabolism. To complete the picture, the level of sterol regulatory element binding proteins (SREBPs), SREBP cleavage activating protein, and insulin\u2010induced gene has been measured. The levels of other related proteins, whose transcription is SREBP dependent, that is low density lipoprotein receptor (LDLr) and Caveolin 1, have been also measured. The age\u2010related reduced Insigs levels, joined to a reduced insulin sensitivity, could explain the decreased degradation rate of the HMG\u2010CoAR and the increased active SREBP\u20102. The SREBP\u20102 in particular seems to be committed in multiple way to gene transcription. The obtained data represent a good contribution to explain the age\u2010related hypercholesterolemia. J. Cell. Biochem. 98: 1044\u20131053, 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcb.20951","type":"journal-article","created":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T21:55:20Z","timestamp":1149198920000},"page":"1044-1053","source":"Crossref","is-referenced-by-count":32,"title":["Modified HMG\u2010CoA reductase and LDLr regulation is deeply involved in age\u2010related 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