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We have compared gene expression in normal germinal center centroblasts, centrocytes, lymphoblastoid cells undergoing induced UPR, and the CCL155 plasmacytoma cell line. In the centroblast to centrocyte transition there is a change in the expression of a relatively small number of genes. These include a limited subset of the genes upregulated by a fully activated UPR as well as a small number of other transcription factors, some disulphide isomerases, and other genes. This is consistent with a model in which this transition is mediated by changes in the levels of expression of transcription factor B\u2010lymphocyte\u2010induced maturation protein 1 (Blimp1) (PRDM1), BACH2, X\u2010box binding protein 1 (XBP1), interferon regulatory factor 4 (IRF4), and possibly vitamin D receptor (VDR) expression, together with post\u2010transcriptional changes and a limited induction of aspects of the UPR. J. Cell. Biochem. 99: 1308\u20131325, 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcb.20952","type":"journal-article","created":{"date-parts":[[2006,6,22]],"date-time":"2006-06-22T20:34:22Z","timestamp":1151008462000},"page":"1308-1325","source":"Crossref","is-referenced-by-count":23,"title":["A limited number of genes are involved in the differentiation of germinal center B cells"],"prefix":"10.1002","volume":"99","author":[{"given":"Yasuhiro","family":"Nakayama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Stabach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen E.","family":"Maher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milind 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