{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:27:12Z","timestamp":1789064832773,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,10,24]],"date-time":"2006-10-24T00:00:00Z","timestamp":1161648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2006,10,24]],"date-time":"2006-10-24T00:00:00Z","timestamp":1161648000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2007,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Usually mast cells (MCs) modulate other cellular activities through the release of their cytoplasmic granules. Recently, gap junctional intercellular communication (GJIC) between an established human MC cell line (HMC\u20101) co\u2010cultured with human dermal fibroblasts in fibroblast populated collagen lattices (FPCLs), enhanced the rate and degree of FPCL contraction. However, HMC\u20101 cells were unable to generate GJIC with human neonatal fibroblasts in monolayer culture. Here freshly isolated rat peritoneal MCs are co\u2010cultured with fibroblasts in collagen lattices and in monolayer culture\n                    <jats:italic>in vitro<\/jats:italic>\n                    and introduced into rat polyvinyl alcohol (PVA) sponge implants\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Co\u2010cultured MC\u2010FPCL contracted faster and to a greater degree. Loading Calcein AM green fluorescent dye into red fluorescent Dil tagged MC generates MC\u2010paratroopers. When MC\u2010paratroopers form GJIC with fibroblasts, some green dye is passed into the fibroblast, while the MC\u2010paratrooper retains both its red and green fluorescence. MC\u2010paratroopers passed green fluorescent dye into both human and rat dermal fibroblasts in monolayer culture. In rats 7\u2010day\u2010old subcutaneous PVA sponge implants, which received an injection of MC\u2010paratroopers, exhibited auto\u2010fluorescent green fibroblasts, when harvested 24 h later. MC\u2010paratroopers pretreated with a long\u2010acting GJIC inhibitor prior to their introduction into PVA sponge implants, failed to pass dye into fibroblasts. It is proposed that GJIC between granulation tissue fibroblasts and MCs can modulate some aspects of wound repair and fibrosis. J. Cell. Biochem. 100: 1170\u20131177, 2007. \u00a9 2006 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/jcb.21107","type":"journal-article","created":{"date-parts":[[2006,10,24]],"date-time":"2006-10-24T21:15:41Z","timestamp":1161724541000},"page":"1170-1177","source":"Crossref","is-referenced-by-count":35,"title":["Rat mast cells communicate with fibroblasts via gap junction intercellular communications"],"prefix":"10.1002","volume":"100","author":[{"given":"Stephen R.","family":"Au","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Au","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory C.","family":"Saggers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neel","family":"Karne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Paul","family":"Ehrlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-0388"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.3.1274"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.9.4810"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22529.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(88)90050-1"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119290"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890310012094"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(03)00007-9"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.2003.11616.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(200007)184:1<86::AID-JCP9>3.0.CO;2-5"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20852"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2002.01293.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2001.100503.x"},{"key":"e_1_2_5_15_1","first-page":"490","article-title":"A preloading method of evaluating gap junctional communication by fluorescent dye transfer","volume":"18","author":"Goldberg GS","year":"1995","journal-title":"Biotechniques"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.158.5.2310"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.139.7.1785"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(18)30221-3"},{"key":"e_1_2_5_19_1","first-page":"327","article-title":"The mast cell in hypertrophic scars","volume":"30","author":"Kischer CW","year":"1972","journal-title":"Tex Rep Biol Med"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12543553"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00638"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81282-9"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.143.6.1735"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00098.2005"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2004.012310.x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.115.5.1357"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004030050351"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000147778"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113578"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000049451.38505.45"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007075628316"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004630-198703000-00008"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.160.10.5053"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(200001)190:1<100::AID-PATH496>3.0.CO;2-Q"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000189"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200211000-00009"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2000.00973.x"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.21107","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.21107","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcb.21107","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.21107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:32:24Z","timestamp":1783009944000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.21107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,24]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,4,1]]}},"alternative-id":["10.1002\/jcb.21107"],"URL":"https:\/\/doi.org\/10.1002\/jcb.21107","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,24]]}}}