{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T21:19:14Z","timestamp":1722806354967},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,12]],"date-time":"2006-12-12T00:00:00Z","timestamp":1165881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cell cycle progression beyond the G<jats:sub>1<\/jats:sub>\/S phase transition requires the activation of a transcription complex containing histone nuclear factor P (HiNF\u2010P) and nuclear protein mapped to ataxia telangiectasia (p220<jats:sup>NPAT<\/jats:sup>) in response to cyclin dependent kinase 2 (CDK2)\/cyclin E signaling. We show here that the potent co\u2010activating properties of HiNF\u2010P\/p220<jats:sup>NPAT<\/jats:sup> on the histone H4 gene promoter, which are evident in the majority of human cell types, are sporadically neutralized in distinct somatic cell lines. In cells where HiNF\u2010P and p220<jats:sup>NPAT<\/jats:sup> do not activate the H4 gene promoter, HiNF\u2010P instead represses transcription. Our data suggest that the cell type specific expression of the cyclin\u2010dependent kinase inhibitory (CKI) protein p57<jats:sup>KIP2<\/jats:sup> inhibits the HiNF\u2010P dependent activation of the histone H4 promoter. We propose that, analogous to E2F proteins and other cell cycle regulatory proteins, HiNF\u2010P is a bifunctional transcriptional regulator that can activate or repress cell cycle controlled genes depending on the cellular context. J. Cell. Biochem. 101: 181\u2013191, 2007. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcb.21157","type":"journal-article","created":{"date-parts":[[2006,12,12]],"date-time":"2006-12-12T18:38:09Z","timestamp":1165948689000},"page":"181-191","source":"Crossref","is-referenced-by-count":13,"title":["HiNF\u2010P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription"],"prefix":"10.1002","volume":"101","author":[{"given":"Partha","family":"Mitra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronglin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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