{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:46:39Z","timestamp":1791085599552,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,1,9]],"date-time":"2007-01-09T00:00:00Z","timestamp":1168300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Approximately 25% of patients with colorectal cancer will develop metastatic disease exclusively or largely confined to the liver, and the vast majority of these cases are not amenable to surgical resection. These unresectable cases of liver metastatic disease can be treated with isolated hepatic perfusion (IHP), which involves a method of complete vascular isolation of the liver to allow treatment of liver tumors with toxic systemic doses of chemotherapeutic agents. To improve the efficacy of IHP, hyperthermia and biological agents have been applied along with the chemotherapeutic agents. In this study, we investigated whether hyperthermia in combination with tumor necrosis factor\u2010related apoptosis\u2010inducing ligand (TRAIL) enhances mortality in human colorectal carcinoma CX\u20101 cells. Cells were treated with various concentrations of TRAIL (0\u2013200 ng\/ml) at various temperatures (40\u201346\u00b0C) for 1 h and further incubated at 37\u00b0C in the presence of TRAIL. We observed that hyperthermia at 42\u201343\u00b0C effectively promoted TRAIL\u2010induced apoptosis, as indicated by cell death, poly (ADP\u2010ribose) polymerase (PARP) cleavage, and activation of caspase\u20108, \u20109, and \u20103. In contrast, hyperthermia at 45\u201346\u00b0C suppressed TRAIL\u2010induced apoptosis. We also observed that mild hyperthermia, but not acute hyperthermia, promoted cytochrome <jats:italic>c<\/jats:italic> release during treatment with TRAIL. Our data suggest that promotion of cytochrome <jats:italic>c<\/jats:italic> release during mild hyperthermia is responsible for the enhancement of TRAIL cytotoxicity. J. Cell. Biochem. 101: 619\u2013630, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcb.21203","type":"journal-article","created":{"date-parts":[[2007,1,9]],"date-time":"2007-01-09T23:48:52Z","timestamp":1168386532000},"page":"619-630","source":"Crossref","is-referenced-by-count":16,"title":["Effect of hyperthermia on TRAIL\u2010induced apoptotic death in human colon cancer cells: Development of a novel strategy for regional therapy"],"prefix":"10.1002","volume":"101","author":[{"given":"Jinsang","family":"Yoo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong 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