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The efficacy of the current therapies based on antibiotics against <jats:italic>H. pylori<\/jats:italic> has been limited by difficulties such as antibiotic resistance and recurrence. As a consequence, the development of promising vaccines was prompted as the best preventive measure. Unfortunately, so far vaccines failed the transition from animal models to human trials. This keynote presentation is to provide a bird's eye view of <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic>\u2010related gastric diseases, including gastric cancer, with a synthesis of the molecular mechanisms involved, and an exhaustive presentation and discussion of the current therapeutic guidelines and future strategies for prevention or therapy. J. Cell. 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