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This complication is receiving increased attention because T1\u2010diabetics are living longer due to better therapeutics, and are faced with their existing health concerns being compounded by complications associated with aging, such as osteoporosis. Both male and female, endochondrial and intra\u2010membranous, and axial and appendicular bones are susceptible to T1\u2010diabetic bone loss. Exact mechanisms accounting for T1\u2010diabetic bone loss are not known. Existing data indicate that the bone defect in T1\u2010diabetes is anabolic rather than catabolic, suggesting that anabolic therapeutics may be more effective in preventing bone loss. Potential contributors to T1\u2010diabetic suppression of bone formation are discussed in this review and include: increased marrow adiposity, hyperlipidemia, reduced insulin signaling, hyperglycemia, inflammation, altered adipokine and endocrine factors, increased cell death, and altered metabolism. Differences between T1\u2010diabetic\u2010 and age\u2010associated bone loss underlie the importance of condition specific, individualized treatments for osteoporosis. Optimizing therapies that prevent bone loss or restore bone density will allow T1\u2010diabetic patients to live longer with strong healthy bones. J. Cell. Biochem. 102: 1343\u20131357, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcb.21573","type":"journal-article","created":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T17:46:35Z","timestamp":1193939195000},"page":"1343-1357","source":"Crossref","is-referenced-by-count":201,"title":["Understanding the pathology and mechanisms of type I diabetic bone loss"],"prefix":"10.1002","volume":"102","author":[{"given":"Laura R.","family":"McCabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.11.4708"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0196-106"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.4.668"},{"key":"e_1_2_15_5_1","first-page":"151","article-title":"Plasticity and regulation of human bone marrow stromal 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