{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T21:44:52Z","timestamp":1757540692929},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,10,24]],"date-time":"2007-10-24T00:00:00Z","timestamp":1193184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2008,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Correlative analyses of tumors and patient\u2010derived cell lines of the human reproductive system suggest that overexpression of EGF contributes to the oncogenic phenotype. However, it is unclear at what stage in disease overexpression of the EGFR is most critical. To assess its role as an initiator of reproductive tissue tumor development, transgenic mice were derived with mouse mammary tumor virus (MMTV)\u2010regulated overexpression of the human EGFR. Although elevated expression of the EGFR in hormonally responsive tissues was observed, only one EGFR transgenic mouse developed a visible tumor over a 2\u2010year period. However, of 12 females monitored over the same time, hyperplasia, hypertrophy, or slight dysplasia was found in mammary glands of 55% of the animals examined, in the uterus or uterine horn of 89%, and in ovaries or oviducts of 100%. None of the reproductive tissues of the male transgenic animals or age\u2010matched, normal mice displayed these changes. These results revealed a role for the EGFR in the initiation of ovarian and uterine cancer and supported previous studies in breast cancer that the receptor can contribute to the neoplastic process in a significant albeit incremental way. J. Cell. Biochem. 103: 2010\u20132018, 2008. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcb.21591","type":"journal-article","created":{"date-parts":[[2007,10,24]],"date-time":"2007-10-24T14:13:30Z","timestamp":1193235210000},"page":"2010-2018","source":"Crossref","is-referenced-by-count":9,"title":["MMTV\u2010EGF receptor transgene promotes preneoplastic conversion of multiple steroid hormone\u2010responsive tissues"],"prefix":"10.1002","volume":"103","author":[{"given":"Nadzeya V.","family":"Marozkina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven M.","family":"Stiefel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Henry F.","family":"Frierson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah J.","family":"Parsons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,10,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2153(08)60257-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00666188"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001090050076"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60774-5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.12.8335"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.16.7059-7071.2004"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203520"},{"issue":"8","key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1242\/dev.126.8.1631","article-title":"Smad5 knockout mice die at mid\u2010gestation due to multiple embryonic and extraembryonic defects","volume":"126","author":"Chang H","year":"1999","journal-title":"Development"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2005.06.005"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00666179"},{"key":"e_1_2_6_12_1","first-page":"3438","article-title":"Expression of epidermal growth factor receptor correlates with disease relapse and progression to androgen\u2010independence in human prostate cancer","volume":"8","author":"Di Lorenzo G","year":"2002","journal-title":"Clin Cancer Res"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gah207"},{"key":"e_1_2_6_14_1","first-page":"259","article-title":"Transgenic models of human cancer","volume":"22","author":"Hinrichs SH","year":"1991","journal-title":"Princess Takamatsu Symp"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81688-8"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2004.09.001"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0508521102"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2005.02.003"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90076-Q"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3536"},{"key":"e_1_2_6_21_1","first-page":"1781","article-title":"NDF\/heregulin induces persistence of terminal end buds and adenocarcinomas in the mammary glands of transgenic mice","volume":"12","author":"Krane IM","year":"1996","journal-title":"Oncogene"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208712"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-005-9011-0"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00718595"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00050793"},{"issue":"10","key":"e_1_2_6_26_1","doi-asserted-by":"crossref","first-page":"5726","DOI":"10.1128\/MCB.16.10.5726","article-title":"Synergistic interaction of the Neu proto\u2010oncongene product and transforming growth factor alpha in the mammary epithelium of transgenic mice","volume":"16","author":"Muller WJ","year":"1996","journal-title":"Mol Cell Biol"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.13.3159"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/21.19.4632"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1157\/13083345"},{"issue":"8547","key":"e_1_2_6_30_1","first-page":"1398","article-title":"Epidermal\u2010growth\u2010factor receptor status as predictor of early recurrence of and death from breast cancer","volume":"1","author":"Sainsbury JR","year":"1987","journal-title":"Lancet"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/1040-8428(94)00144-I"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00114-8"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.14.11.7068"},{"issue":"6","key":"e_1_2_6_34_1","first-page":"4261","article-title":"Cancer of the uterine cervix is susceptible to anti\u2010EGF\u2010R antibody EMD 55,900 therapy","volume":"25","author":"Solbach C","year":"2005","journal-title":"Anticancer Res"},{"issue":"4","key":"e_1_2_6_35_1","first-page":"1772","article-title":"Functional heterogeneity of proto\u2010oncogene tyrosine kinases: The C terminus of the human epidermal growth factor receptor facilitates cell proliferation","volume":"9","author":"Velu TJ","year":"1989","journal-title":"Mol Cell Biol"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.2.335"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21831"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2003-0222"},{"key":"e_1_2_6_39_1","first-page":"147","article-title":"Epithelial cell migration in response to epidermal growth factor","volume":"327","author":"Zeineldin R","year":"2006","journal-title":"Methods Mol Biol"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.21591","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.21591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T17:28:22Z","timestamp":1697650102000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.21591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,24]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,4,15]]}},"alternative-id":["10.1002\/jcb.21591"],"URL":"https:\/\/doi.org\/10.1002\/jcb.21591","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,24]]}}}