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In this present study, we showed that tanshinone IIA, the major lipid\u2010soluble pharmacological constituent of <jats:italic>Salvia miltiorrhiza<\/jats:italic> BUNGE, inhibits human aortic smooth muscle cell (HASMC) migration and MMP\u20109 activity. Tanshinone IIA significantly inhibited I\u03baB\u03b1 phosphorylation and p65 nuclear translocation through inhibition of AKT phosphorylation. Tanshinone IIA inhibited TNF\u2010\u03b1\u2010induced ERK and c\u2010jun phosphorylation, but not other MAPKs such as JNK and p38. Tanshinone IIA also inhibited NF\u2010\u03baB and AP\u20101 DNA\u2010binding. Moreover, tanshinone IIA inhibited the migration of TNF\u2010\u03b1\u2010induced HASMCs. Our results provide evidence that tanshinone IIA has multiple effects in the inhibition of HASMC migration and may offer a therapeutic approach to block HASMC migration. J. Cell. Biochem. 104: 15\u201326, 2008. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcb.21599","type":"journal-article","created":{"date-parts":[[2007,11,2]],"date-time":"2007-11-02T16:59:44Z","timestamp":1194022784000},"page":"15-26","source":"Crossref","is-referenced-by-count":87,"title":["Tanshinone IIA from <i>Salvia miltiorrhiza<\/i> BUNGE inhibits human aortic smooth muscle cell migration and MMP\u20109 activity through AKT signaling pathway"],"prefix":"10.1002","volume":"104","author":[{"given":"Un\u2010Ho","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok\u2010Jong","family":"Suh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyen 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