{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T20:30:14Z","timestamp":1777062614502,"version":"3.51.4"},"reference-count":79,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,2,4]],"date-time":"2008-02-04T00:00:00Z","timestamp":1202083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Type 1 diabetes<\/jats:italic> results from the T cell\u2010mediated destruction of pancreatic beta cells. Islet transplantation has recently become a potential therapeutic approach for patients with type 1 diabetes. However, islet\u2010graft failure appears to be a challenging issue to overcome. Thus, complementary gene therapy strategies are needed to improve the islet\u2010graft survival following transplantation. Immune modulation through gene therapy represents a novel way of attacking cytotoxic T cells targeting pancreatic islets. Various death ligands of the TNF family such as FasL, TNF, and TNF\u2010Related Apoptosis\u2010Inducing Ligand (TRAIL) have been studied for this purpose. The over\u2010expression of TNF or FasL in pancreatic islets exacerbates the onset of type 1 diabetes generating lymphocyte infiltrates responsible for the inflammation. Conversely, the lack of TRAIL expression results in higher degree of islet inflammation in the pancreas. In addition, blocking of TRAIL function using soluble TRAIL receptors facilitates the onset of diabetes. These results suggested that contrary to what was observed with TNF or FasL, adenovirus mediated TRAIL gene delivery into pancreatic islets is expected to be therapeutically beneficial in the setting of experimental models of <jats:italic>type 1 diabetes<\/jats:italic>. In conclusion; this study mainly reveals the fundamental principles of death ligand\u2010mediated immune evasion in diabetes mellitus. J. Cell. Biochem. 104: 710\u2013720, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcb.21677","type":"journal-article","created":{"date-parts":[[2008,2,4]],"date-time":"2008-02-04T16:49:02Z","timestamp":1202143742000},"page":"710-720","source":"Crossref","is-referenced-by-count":27,"title":["Molecular mechanisms of death ligand\u2010mediated immune modulation: A gene therapy model to prolong islet survival in type 1 diabetes"],"prefix":"10.1002","volume":"104","author":[{"given":"Ahter Dilsad","family":"Sanlioglu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas S.","family":"Griffith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulkadir","family":"Omer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ercument","family":"Dirice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramazan","family":"Sari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan Ali","family":"Altunbas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa Kemal","family":"Balci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salih","family":"Sanlioglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,2,4]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"S8","article-title":"Role of the C D28: B7 costimulatory interaction in alloimmune responses","volume":"58","author":"Akalin E","year":"1997","journal-title":"Kidney Int Suppl"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.8.3943"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(99)80034-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051080"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2006.111"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/1043034041648426"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M011183200"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.11.1936"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe068183"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i2.334"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80178-6"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpa.0000148515.77497.4b"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00043.2006"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1385\/IR:36:1:83"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80399-4"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.11.6539"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250100021"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0508166103"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2004.04.004"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80670-6"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(98)80224-0"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.5.2886"},{"key":"e_1_2_9_24_1","first-page":"3093","article-title":"Induction and regulation of tumor necrosis factor\u2010related apoptosis\u2010inducing ligand\/Apo\u20102 ligand\u2010mediated apoptosis in renal cell carcinoma","volume":"62","author":"Griffith TS","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199712150-00011"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1392"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2001.281.6.G1357"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.10.2219"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.176.6.1719"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830270138"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302260"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cgt.7700749"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.162.5.2639"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610690104"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.12.3964-3973.2001"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.1.213"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.9.2274"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-0039-9"},{"key":"e_1_2_9_39_1","first-page":"1199","article-title":"CMV\u2010hFasL transgenic mice are sensitive to low doses of streptozotocin\u2010induced type I diabetes mellitus","volume":"24","author":"Lin B","year":"2003","journal-title":"Acta Pharmacol Sin"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1070"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(02)00422-8"},{"key":"e_1_2_9_42_1","first-page":"1","volume-title":"Diabetes 1994\u20132010: Global estimates and projections","author":"McCarty D","year":"1994"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0619"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.8.1967"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.11.4079"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/3276"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2005-0268"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-002-0926-2"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2004.12.002"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb02970.x"},{"key":"e_1_2_9_51_1","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.4049\/jimmunol.150.9.4136","article-title":"Transgenic tumor necrosis factor (TNF)\u2010alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF\u2010alpha and TNF\u2010beta transgenic mice","volume":"150","author":"Picarella DE","year":"1993","journal-title":"J Immunol"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.2.342"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/35070096"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2006.02.002"},{"key":"e_1_2_9_55_1","first-page":"113","article-title":"Current progress in adenovirus mediated gene therapy for patients with prostate carcinoma","volume":"7","author":"Sanlioglu AD","year":"2003","journal-title":"Gene Ther Mol Biol"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-5-54"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cgt.7700877"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cgt.7701087"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.08.087"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.03.057"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e318158a4e5"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(01)00276-X"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-200110000-00005"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0672-6"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.161.9.4484"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000157300.53976.2A"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012350"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.7.1095"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401846"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.3727\/000000002783985503"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.12.2045"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050909"},{"key":"e_1_2_9_73_1","doi-asserted-by":"crossref","first-page":"518","DOI":"10.4049\/jimmunol.162.1.518","article-title":"Accelerated rejection of Fas ligand\u2010expressing heart grafts","volume":"162","author":"Takeuchi T","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0198-031"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel448"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612054546743"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90057-8"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/4401123a"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050574"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.3.708"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.21677","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.21677","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T07:34:02Z","timestamp":1695972842000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.21677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,4]]},"references-count":79,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1002\/jcb.21677"],"URL":"https:\/\/doi.org\/10.1002\/jcb.21677","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,4]]}}}