{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T19:04:07Z","timestamp":1772823847293,"version":"3.50.1"},"reference-count":66,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,7,24]],"date-time":"2008-07-24T00:00:00Z","timestamp":1216857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vitamin D is a principal regulator of calcium homeostasis. However, recent evidence has indicated that vitamin D can have numerous other physiological functions including inhibition of proliferation of a number of malignant cells including breast and prostate cancer cells and protection against certain immune mediated disorders including multiple sclerosis (MS). The geographic incidence of MS indicates an increase in MS with a decrease in sunlight exposure. Since vitamin D is produced in the skin by solar or UV irradiation and high serum levels of 25\u2010hydroxyvitamin D (25(OH)D) have been reported to correlate with a reduced risk of MS, a protective role of vitamin D is suggested. Mechanisms whereby the active form of vitamin D, 1,25\u2010dihydroxyvitamin D<jats:sub>3<\/jats:sub> (1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>) may act to mediate this protective effect are reviewed. Due to its immunosuppressive actions, it has been suggested that 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> may prevent the induction of MS. J. Cell. Biochem. 105: 338\u2013343, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcb.21858","type":"journal-article","created":{"date-parts":[[2008,7,24]],"date-time":"2008-07-24T19:48:59Z","timestamp":1216928939000},"page":"338-343","source":"Crossref","is-referenced-by-count":56,"title":["Vitamin D and multiple sclerosis"],"prefix":"10.1002","volume":"105","author":[{"given":"Anita","family":"Raghuwanshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sneha S.","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia","family":"Christakos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.36.21"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.15.10.5789"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-57-6-1308"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(86)90291-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.15.7861"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/128.1.68"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"5314","DOI":"10.4049\/jimmunol.160.11.5314","article-title":"1,25\u2010dihydroxyvitamin D3 is a positive regulator for the two anti\u2010encephalitogenic cytokines TGF\u2010beta 1 and IL\u20104","volume":"160","author":"Cantorna MT","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/129.11.1966"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.2000.1765"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.10423"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1402.070"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199810)28:10<3017::AID-IMMU3017>3.0.CO;2-6"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1050"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.6.1689S"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0433rev"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000227035.93199.e0"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(90)90005-B"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.57.6.418"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1983.244.3.E266"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207237408709630"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.5.1367"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.121172198"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.5.968"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.1.6"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.09.011"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/77.1.204"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/000456329403100105"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/61.3.638S"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00060793-200202000-00011"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0395-5"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1967.tb05733.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100720070055"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115072"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.4.2060"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00403372"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-64-6-1165"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.75.4.1099"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200002)30:2<498::AID-IMMU498>3.0.CO;2-Q"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.082100699"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.23.2832"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20826"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(01)00360-5"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.131029498"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21382"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.5.2405"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-0618(99)00002-2"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-8467(02)00036-7"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(00)00052-4"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/19783"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.10.3385"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(88)91260-1"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.6.1746"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.6.4119"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.9.6030"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00496810"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6977846"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00315837"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2002-0363"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113009"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.17.10338"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1159\/000054783"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7410.316"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2006.12.094"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/69.5.842"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-67-2-373"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.21858","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.21858","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T03:31:27Z","timestamp":1696908687000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.21858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,24]]},"references-count":66,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["10.1002\/jcb.21858"],"URL":"https:\/\/doi.org\/10.1002\/jcb.21858","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,24]]}}}