{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:53:57Z","timestamp":1791093237376,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,8,26]],"date-time":"2008-08-26T00:00:00Z","timestamp":1219708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2008,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Exposure to radiation provokes cellular responses controlled in part by gene expression networks. MicroRNAs (miRNAs) are small non\u2010coding RNAs which mostly regulate gene expression by degrading the messages or inhibiting translation. Here, we investigated changes in miRNA expression patterns after low (0.1 Gy) and high (2.0 Gy) doses of X\u2010ray in human fibroblasts. At early (0.5 h) and late (6 and 24 h) time points, irradiation caused qualitative and quantitative differences in the down\u2010regulation of miRNA levels, including miR\u201092b, 137, 660, and 656. A transient up\u2010regulation of miRNAs was observed after 2 h post\u2010irradiation following high doses of radiation, including miR\u2010558 and 662. MicroRNA levels were inversely correlated with targets from mRNA and proteomic profiling after 2.0 Gy of radiation. MicroRNAs miR\u2010579, 608, 548\u20103p, and 585 are noted for targeting genes involved in radioresponsive mechanisms, such as cell cycle checkpoint and apoptosis. We suggest here a model in which miRNAs may act as \u201chub\u201d regulators of specific cellular responses, immediately down\u2010regulated so as to stimulate DNA repair mechanisms, followed by up\u2010regulation involved in suppressing apoptosis for cell survival. Taken together, miRNAs may mediate signaling pathways in sequential fashion in response to radiation, and may serve as biodosimetric markers of radiation exposure. J. Cell. Biochem. 105: 824\u2013834, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcb.21878","type":"journal-article","created":{"date-parts":[[2008,8,26]],"date-time":"2008-08-26T13:20:54Z","timestamp":1219756854000},"page":"824-834","source":"Crossref","is-referenced-by-count":80,"title":["Changes in MicroRNA expression patterns in human fibroblasts after low\u2010LET radiation"],"prefix":"10.1002","volume":"105","author":[{"given":"Olivier 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