{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:03Z","timestamp":1786977963761,"version":"build-2736575974"},"reference-count":110,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,11,11]],"date-time":"2008-11-11T00:00:00Z","timestamp":1226361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2008,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Existing data indicate that sleep\u2013wakefulness is an essential behavior. The biological function(s) of sleep, however, remains unknown, due, in part, to the lack of information available at the intracellular level. Preliminary microarray analyses show that changes in behavioral state influence regional mRNA profiles; however, the impact of sleep on protein signatures is virtually unexplored. In these studies, cortical protein profiles were examined after timed bouts of spontaneous sleep\u2013wakefulness. Within minutes of each behavioral state examined, a small number of spots showing unique expression were detected. Mass spectroscopy analyses of sleep\u2010 and wake\u2010related spots identified proteins associated with multiple functional categories. Two sleep\u2010associated proteins were further validated using a sleep deprivation paradigm. We found preliminary evidence for two different post\u2010transcriptional mechanisms\u2014one (GAPDH) in which the amount of protein was increased in the recovery sleep following prolonged waking, while the other (actin) suggested that post\u2010translational modifications may underlie sleep. The similarities between the effects of sleep on both protein and mRNA profiles indicate that dynamic intracellular changes underlie sleep\u2013wake states and are consistent with roles for sleep in multiple biological functions. J. Cell. Biochem. 105: 1472\u20131484, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcb.21970","type":"journal-article","created":{"date-parts":[[2008,11,11]],"date-time":"2008-11-11T11:02:20Z","timestamp":1226401340000},"page":"1472-1484","source":"Crossref","is-referenced-by-count":14,"title":["Rapid alterations in cortical protein profiles underlie spontaneous sleep and wake bouts"],"prefix":"10.1002","volume":"105","author":[{"given":"Jacqueline","family":"Vazquez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Ewa","family":"Witkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Ann","family":"Greco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,11,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.10.2.487"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)60070-9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.29.17582"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150180333"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.38.27119"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.7.3762"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2173-06.2006"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1143"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20675"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(94)00057-O"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01974-06"},{"key":"e_1_2_6_13_1","first-page":"195","article-title":"A two process model of sleep regulation","volume":"1","author":"Borbely AA","year":"1982","journal-title":"Human Neurobiol"},{"key":"e_1_2_6_14_1","first-page":"557","article-title":"Sleep homeostasis and models of sleep regulation","volume":"14","author":"Borbely AA","year":"1999","journal-title":"J Biol Rhythms"},{"key":"e_1_2_6_15_1","first-page":"377","volume-title":"Principles and practices of sleep medicine","author":"Borbely AA","year":"2000"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858406292647"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/JBB\/2006\/35936"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0149-7634(84)90054-X"},{"key":"e_1_2_6_19_1","first-page":"15","volume-title":"Principles and practice of sleep medicine","author":"Carskadon MA","year":"2000"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01786.x"},{"key":"e_1_2_6_21_1","first-page":"11","article-title":"Changes in anti\u2010phosphoserine and anti\u2010phosphothreonine antibody binding during the sleep\u2010waking cycle and after lesions of the locus coeruleus","volume":"1","author":"Cirelli C","year":"1998","journal-title":"Sleep Res Online"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/smrv.2001.0160"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00814-6"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4845-04.2005"},{"key":"e_1_2_6_25_1","volume-title":"Guide for the care and use of laboratory animals","author":"Council NR","year":"1996"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199808240-00031"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.02.046"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(01)00325-6"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-867080"},{"key":"e_1_2_6_30_1","first-page":"2","article-title":"Control of sleep\u2010wake cycles by the mammalian suprachiasmatic pacemaker","volume":"1","author":"Edgar DM","year":"1995","journal-title":"Brain Res Bull"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2005.02.003"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.10075"},{"key":"e_1_2_6_33_1","first-page":"R198","article-title":"Sleep deprivation in rats: Effects on EEG power spectra, vigilance states, and cortical temperature","volume":"261","author":"Franken P","year":"1991","journal-title":"Am J Physiol"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1992.tb05395.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1980.tb08997.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.01134.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.66.1.39-63.2002"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00201-8"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.05.032"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.115287"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.3.1720"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(00)00283-5"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90405-0"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.292.5518.929"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1089\/08977150260139101"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(03)45011-5"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.06.026"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2006.03.005"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(94)90125-2"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1053\/smrv.2000.0116"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4283-04.2005"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.01.019"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01687.x"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.08.005"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5492.754"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(90)90081-K"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1080\/102538902900012323"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.11.043"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.1218"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02952.x"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1997.tb01397.x"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00416-N"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00476-06"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/27.7.1255"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0898-6568(98)00063-1"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2005.01.002"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2004.05.002"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150190613"},{"key":"e_1_2_6_69_1","volume-title":"The rat brain in sterotaxic coordinates","author":"Paxinos G","year":"1982"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(99)00126-6"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.05.014"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.05.006"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)02118-4"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200208070-00007"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(90)90220-X"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1353\/pbm.1998.0051"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4037-06.2007"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/30.12.1643"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.2741\/1174"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200406007"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.24.11205"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/417287a"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2003.12.004"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200400961"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(97)00064-2"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00065-5"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2005.06.004"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(02)00033-5"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(94)90134-1"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748730404269151"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00695-4"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.08.059"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(70)90162-9"},{"key":"e_1_2_6_94_1","first-page":"72","volume-title":"Principles and practice of sleep medicine","author":"Tobler I","year":"2000"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(86)90044-1"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(90)90161-7"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2003.09.004"},{"key":"e_1_2_6_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2005.05.002"},{"key":"e_1_2_6_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1980"},{"key":"e_1_2_6_100_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1883"},{"key":"e_1_2_6_101_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/26.2.117"},{"key":"e_1_2_6_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)90217-2"},{"key":"e_1_2_6_103_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/30.12.1631"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn2035"},{"key":"e_1_2_6_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/0065-2571(94)00013-S"},{"key":"e_1_2_6_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)60068-0"},{"key":"e_1_2_6_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(05)80208-8"},{"key":"e_1_2_6_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2004.08.012"},{"key":"e_1_2_6_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200305389"},{"key":"e_1_2_6_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200305375"},{"key":"e_1_2_6_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.03.063"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcb.21970","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.21970","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T05:17:48Z","timestamp":1696828668000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.21970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,11]]},"references-count":110,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,12,15]]}},"alternative-id":["10.1002\/jcb.21970"],"URL":"https:\/\/doi.org\/10.1002\/jcb.21970","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,11]]}}}