{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:54:42Z","timestamp":1791510882892,"version":"4.3.4"},"reference-count":71,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,2,9]],"date-time":"2009-02-09T00:00:00Z","timestamp":1234137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2009,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>MFG\u2010E8 was initially identified as a principle component of the Milk Fat Globule, a membrane\u2010encased collection of proteins and triglycerides that bud from the apical surface of mammary epithelia during lactation. It has since been independently identified in many species and by many investigators and given a variety of names, including p47, lactadherin, rAGS, PAS6\/7, and BA\u201046. The acronym SED1 was proposed to bring cohesion to this nomenclature based upon it being a <jats:italic>S<\/jats:italic>ecreted protein that contains two distinct functional domains: an N\u2010terminal domain with two <jats:italic>E<\/jats:italic>GF\u2010repeats, the second of which has an integrin\u2010binding RGD motif, and a C\u2010terminal domain with two <jats:italic>D<\/jats:italic>iscoidin\/F5\/8C domains that bind to anionic phospholipids and\/or extracellular matrices. SED1\/MFG\u2010E8 is now known to participate in a wide variety of cellular interactions, including phagocytosis of apoptotic lymphocytes and other apoptotic cells, adhesion between sperm and the egg coat, repair of intestinal mucosa, mammary gland branching morphogenesis, angiogenesis, among others. This article will explore the various roles proposed for SED1\/MFG\u2010E8, as well as its provocative therapeutic potential. J. Cell. Biochem. 106: 957\u2013966, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcb.22076","type":"journal-article","created":{"date-parts":[[2009,2,9]],"date-time":"2009-02-09T17:01:32Z","timestamp":1234198892000},"page":"957-966","source":"Crossref","is-referenced-by-count":149,"title":["SED1\/MFG\u2010E8: A Bi\u2010Motif protein that orchestrates diverse cellular interactions"],"prefix":"10.1002","volume":"106","author":[{"given":"Adam","family":"Raymond","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Ensslin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry 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