{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:41:05Z","timestamp":1782819665012,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,9,16]],"date-time":"2009-09-16T00:00:00Z","timestamp":1253059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present study is aimed to explore the impact of experimental diabetes and insulin replacement on epididymal secretory products, sperm count, motility, and fertilizing ability in albino rats. Prepubertal and adult male Wistar strain rats were made diabetic with a single intraperitoneal injection of streptozotocin (STZ), at 120 and 65\u2009mg\/kg body weight for prepubertal and adult rats, respectively. After 3 days of STZ administration, insulin was given to a group of diabetic rats at a dose of 3\u2009U\/100\u2009g body weight, subcutaneously and killed after 20 days of treatment. STZ\u2010diabetes significantly reduced the epididymal tissue concentrations of testosterone, androgen\u2010binding protein, sialic acid, glycerylphosphoryl choline, and carnitine, suggesting its adverse effects on the secretory activity and concentrating capacity of epididymal epithelium. Impaired cauda epididymidal sperm motility and fertility (in vivo) of STZ\u2010diabetic rats imply the defective sperm maturation. Insulin replacement prevented these changes either partially or completely. From the above findings, it is evident that STZ\u2010diabetes has an adverse effect on sperm maturation, which may be due to the decrease in the bioavailability of testosterone and epididymal secretory products. J. Cell. Biochem. 108: 1094\u20131101, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcb.22337","type":"journal-article","created":{"date-parts":[[2009,9,16]],"date-time":"2009-09-16T19:50:10Z","timestamp":1253130610000},"page":"1094-1101","source":"Crossref","is-referenced-by-count":40,"title":["Impact of experimental diabetes and insulin replacement on epididymal secretory products and sperm maturation in albino rats"],"prefix":"10.1002","volume":"108","author":[{"given":"Soudamani","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thayman","family":"Malini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasan","family":"Rengarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karundevi","family":"Balasubramanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,9,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1013433"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901031"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.1978.tb00510.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(75)90057-X"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod25.5.1099"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"8227","DOI":"10.1016\/S0021-9258(19)43218-3","article-title":"Accumulation of carnitine by bovine spermatozoa during maturation in the epididymis","volume":"248","author":"Casillas ER","year":"1973","journal-title":"J Biol Chem"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(76)90172-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-127-6-2829"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/01485019008987617"},{"key":"e_1_2_7_11_1","first-page":"371","volume-title":"The epididymis: From molecules to clinical practices","author":"Ezer N","year":"2002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2004.05.011"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1991.tb27319.x"},{"key":"e_1_2_7_14_1","first-page":"259","volume-title":"Handbook of physiology. 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