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Bone disease is a hallmark of MM, and myeloma bone disease differs from bone metastasis caused by other tumors. Although myeloma and other osteolytic metastases induce increased osteoclastic bone destruction, in contrast to other tumors, once myeloma tumor burden exceeds 50% in a local area, osteoblast activity is either severely depressed or absent. The basis for this severe imbalance between increased osteoclastic bone resorption and decreased bone formation has been the topic of intensive investigation over the last several years. These studies have helped to identify novel targets for treating myeloma bone disease and will be discussed in this chapter. J. Cell. Biochem. 109: 283\u2013291, 2010. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcb.22403","type":"journal-article","created":{"date-parts":[[2009,12,11]],"date-time":"2009-12-11T20:11:54Z","timestamp":1260562314000},"page":"283-291","source":"Crossref","is-referenced-by-count":128,"title":["Pathogenesis of myeloma bone disease"],"prefix":"10.1002","volume":"109","author":[{"given":"G. 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