{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:00:53Z","timestamp":1791241253261,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,11,29]],"date-time":"2010-11-29T00:00:00Z","timestamp":1290988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2010,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Translational studies have explored the therapeutic effects of stem cells, raising hopes for the treatment of numerous diseases. Here, we evaluated the therapeutic effect of chorionic plate\u2010derived mesenchymal stem cells (CP\u2010MSCs) isolated from human placenta and transplanted into rats with carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)\u2010injured livers. CP\u2010MSCs were analyzed for hepatocyte\u2010specific gene expression, indocyanine green (ICG) uptake, glycogen storage, and urea production following hepatogenic differentiation. PKH26\u2010labeled CP\u2010MSCs were directly transplanted into the livers of rats that had been exposed to CCl<jats:sub>4<\/jats:sub> (1.6\u2009g\/kg, twice per week for 9 weeks). Blood and liver tissue were analyzed at 1, 2, and 3 weeks post\u2010transplantation. The expression of type I collagen (Col I) and matrix metalloproteinases (MMPs) was analyzed in rat T\u2010HSC\/Cl\u20106 hepatic stellate cells co\u2010cultured with CP\u2010MSCs following exposure to TGF\u2010\u03b2. The expression levels of \u03b1\u2010smooth muscle actin (\u03b1\u2010SMA) and Col I were lower in transplanted (TP) rats than in non\u2010transplanted (Non\u2010TP) animals (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), whereas the expression levels of albumin and MMP\u20109 were increased. TP rats exhibited significantly higher uptake\/excretion of ICG than non\u2010TP rats (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.005). In addition, collagen synthesis in T\u2010HSC\/Cl\u20106 cells exposed to TGF\u2010\u03b2 was decreased by co\u2010culture with CP\u2010MSCs, which triggered the activation of MMP\u20102 and MMP\u20109. These results contribute to our understanding of the potential pathophysiological roles of CP\u2010MSCs, including anti\u2010fibrotic effects in liver disease, and provide a foundation for the development of new cell therapy\u2010based strategies for the treatment of difficult\u2010to\u2010treat liver diseases. J. Cell. Biochem. 111: 1453\u20131463, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcb.22873","type":"journal-article","created":{"date-parts":[[2010,9,9]],"date-time":"2010-09-09T15:15:03Z","timestamp":1284045303000},"page":"1453-1463","source":"Crossref","is-referenced-by-count":115,"title":["Anti\u2010fibrotic effect of chorionic plate\u2010derived mesenchymal stem cells isolated from human placenta in a rat model of CCl<sub>4<\/sub>\u2010injured liver: Potential application to the treatment of hepatic diseases"],"prefix":"10.1002","volume":"111","author":[{"given":"Min\u2010Jae","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieun","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu\u2010Hwan","family":"Na","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji 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