{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T22:54:10Z","timestamp":1696978450059},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,1,25]],"date-time":"2011-01-25T00:00:00Z","timestamp":1295913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>RUNX1\/AML1<\/jats:italic> point mutations have been identified in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) patients. A heterozygous germline mutation of the <jats:italic>RUNX1<\/jats:italic> gene causes a familial platelet disorder with a predisposition to AML. <jats:italic>RUNX1<\/jats:italic> mutations have also been detected with high frequency in minimally differentiated AML M0 subtypes and myelodysplastic\/myeloproliferative neoplasms. Here we propose a new disease category of myelodysplastic neoplasms (MDN) consisting of MDS refractory anemia with excess blasts and AML with myelodysplasia\u2010related changes, including therapy\u2010related cases. <jats:italic>RUNX1<\/jats:italic> mutations have been detected in about 20% of patients with \u201cMDN\u201d. Among the MDN cases, histories of radiation exposure, therapy\u2010related myeloid neoplasms after successful treatment for acute promyelocytic leukemia, and leukemic transformation of myeloproliferative neoplasms have been reported to have a strong association with <jats:italic>RUNX1<\/jats:italic> mutations. The mutations occur in a normal, a receptive, or a disease\u2010committed hematopoietic stem cell. It is suspected that the \u201cMDN\u201d phenotypes are defined by the <jats:italic>RUNX1<\/jats:italic> mutations in addition to some other abnormalities. J. Cell. Biochem. 112: 425\u2013432, 2011. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcb.22974","type":"journal-article","created":{"date-parts":[[2010,12,6]],"date-time":"2010-12-06T14:00:26Z","timestamp":1291644026000},"page":"425-432","source":"Crossref","is-referenced-by-count":20,"title":["Molecular mechanisms that produce secondary MDS\/AML by <i>RUNX1\/AML1<\/i> point 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